170941-69-2Relevant academic research and scientific papers
Chelated [3,3]-rearrangements of difluoroallylic alcohols
Broadhurst,Percy,Prime
, p. 5903 - 5906 (2007/10/03)
Whereas the lithium enolates of acetate and propionate esters of difluoroallylic alcohols fragment rapidly, even at -78*C, methoxy- and benzyloxy-acetates form chelated enolates which undergo smooth [3,3]-rearrangement as their silyl ketene acetals. The latent ketone function can be revealed under mild conditions CMeOH,SOCl2) to afford very highly functionalised CF2 compounds.
New Fluorine-containing Building Blocks from Trifluoroethanol. 1.
Patel, Sunita T.,Percy, Jonathan M.,Wilkes, Robin D.
, p. 9201 - 9216 (2007/10/02)
A new fluorine containing acyl anion equivalent 1,1-difluoro-2-lithio-2-ethene 12 has been prepared from trifluoroethanol and trapped with a number of electrophiles in good yield.Effective electrophiles included Group(IV) halides a
