170959-10-1

Basic information

• Product Name: 2-IODO-PIVALOYLANILINE
• Synonyms: 2-IODO-PIVALOYLANILINE
• CAS NO: 170959-10-1
• Molecular Formula: C₁₁H₁₄INO
• Molecular Weight: 303.138
• Mol File: 170959-10-1.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 379°C at 760 mmHg
• Flash Point: 183°C
• Appearance: /
• Density: 1.561g/cm³
• Vapor Pressure: 6.06E-06mmHg at 25°C
• Refractive Index: 1.609
• CAS DataBase Reference: 2-IODO-PIVALOYLANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-IODO-PIVALOYLANILINE(170959-10-1)
• EPA Substance Registry System: 2-IODO-PIVALOYLANILINE(170959-10-1)

Safety Data

• Hazardous Substances Data: 170959-10-1(Hazardous Substances Data)

Usage

General Description

2-IODO-PIVALOYLANILINE is a chemical compound with the molecular formula C14H18IN that is used in research and synthesis applications. It is a derivative of aniline, containing a pivaloyl group and an iodine atom. 2-IODO-PIVALOYLANILINE is a white to off-white solid with a melting point of around 53-57°C, and it is soluble in organic solvents such as acetone and chloroform. 2-IODO-PIVALOYLANILINE is commonly used as a reagent in the synthesis of various organic compounds, and it has been studied for its potential use in medicinal applications. It is important to handle this compound with care and follow proper safety precautions, as it can be hazardous if not handled properly.

InChI:InChI=1/C11H14INO/c1-11(2,3)10(14)13-9-7-5-4-6-8(9)12/h4-7H,1-3H3,(H,13,14)

Upstream product

• 24331-71-3 N,N-dimethylpivalamide 
• 615-43-0 2-iodophenylamine 
• 6625-74-7 N-pivaloylaniline 
• 3282-30-2 pivaloyl chloride 

Downstream Products

• 873913-19-0 N-(2-iodophenyl)-N-methylpivalamide 
• 1434056-60-6 N-(2-(benzylthio)phenyl)pivalamide 
• 92367-59-4 3,3-dimethyl-3,4-dihydroquinolin-2(1H)-one 

Relevant articles and documents

Nickel(II)- And Silver(I)-Catalyzed C-H Bond Halogenation of Anilides and Carbamates

ortho -C-H bond halogenation of anilides and N -aryl carbamates using easily available N -halosuccinimides (NXS) as the active halogenation reagent in the presence of nickel or silver catalyst has been developed. This method provides a new approach to 2-haloanilides and carbamates, which may serve as starting materials for the synthesis of pharmaceutically and biologically active compounds.

Dibrominative Spirocyclization of 2-Butynolyl Anilides: Synthesis of gem-Dibromospirocyclic Benzo[ d][1,3]oxazines and Their Application in the Synthesis of 4 H-Furo[3,2- b]indoles

The combination of catalytic aqueous hydrochloric acid (HCl) and N-bromosuccinimide (NBS) generated electrophilic bromine monochloride (BrCl), which readily induced spiroannulation of 2-alkynolyl anilides (n = 1-3) to form gem-dibromospirocyclic benzo[d][

Para -Selective copper-catalyzed C(sp2)-H amidation/dimerization of anilides via a radical pathway

Copper-catalyzed amidation/dimerization of anilides via regioselective C(sp2)-H functionalization is achieved. The para-selective amidation is accomplished on the anilide aromatic ring via a radical pathway leading to C-N bond formation in the presence of ammonium persulfate as a radical source/oxidant for the copper catalyst. The developed protocol tolerates a wide range of anilide substrates. The regioselectivity is confirmed by single-crystal X-ray studies.