170959-40-7

Basic information

• Product Name: 4-methyl-5-(4-methyl-1,3-oxazol-5-yl)-2,4-dihydro-3H-1,2,4-triazole-3-thione
• Synonyms: 4-methyl-5-(4-methyl-1,3-oxazol-5-yl)-2,4-dihydro-3H-1,2,4-triazole-3-thione;4-Methyl-5-(4-Methyloxazol-5-yl)-4H-1,2,4-triazole-3-thiol;3H-1,2,4-Triazole-3-thione, 2,4-dihydro-4-Methyl-5-(4-Methyl-5-oxazolyl)-;4-Methyl-3-(4-methyloxazol-5-yl)-1H-1,2,4-triazole-5(4H)-thione;2,4-DIHYDRO-4-METHYL-5-(4-METHYL-5-OXAZOLYL)-3H-1,2,4-TRIAZOLE-3-THIONE
• CAS NO: 170959-40-7
• Molecular Formula: C₇H₈N₄OS
• Molecular Weight: 196.23
• Mol File: 170959-40-7.mol
• Article Data: 18

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-methyl-5-(4-methyl-1,3-oxazol-5-yl)-2,4-dihydro-3H-1,2,4-triazole-3-thione(CAS DataBase Reference)
• NIST Chemistry Reference: 4-methyl-5-(4-methyl-1,3-oxazol-5-yl)-2,4-dihydro-3H-1,2,4-triazole-3-thione(170959-40-7)
• EPA Substance Registry System: 4-methyl-5-(4-methyl-1,3-oxazol-5-yl)-2,4-dihydro-3H-1,2,4-triazole-3-thione(170959-40-7)

Safety Data

• Hazardous Substances Data: 170959-40-7(Hazardous Substances Data)

Upstream product

• 2510-32-9 4-methyl-1,3-oxazole-5-carboxylic acid 
• 6610-29-3 4-methylthiosemicarbazide 
• 170959-38-3 C₇H₁₀N₄O₂S 
• 62348-24-7 4-Methyl-5-oxazolecarbonyl chloride 
• 170959-38-3 1-(4-methyloxazole-5-carboxyl)-4-methylthiosemicarbazide 

Relevant articles and documents

A mechanistic insight into a simple c-n bond formation via sn2 displacement: A synergistic kinetics and design of experiment approach

A novel series of 1,2,4-triazol-3-yl-azabicyclo[3.1.0]hexanes was recently identified as new highly potent and selective dopamine (DA) D3 receptor antagonists. This class of molecules deserved the Chemical Development special attention to quantify the reliability and robustness of the pivotal SN2 displacement step between the 1,2,4-triazol-3-yl-halide derivative (4) and variously substituted azabicyclo[3.1.0]hexanes (5). To reach this goal we applied the classical Design of Experiment (DoE) approach, simultaneously trying to build up a descriptive kinetic model of the chemistry. The synergistic use of these two techniques allowed us to select new, higher-yielding and more robust reaction conditions and, at the same time, to identify their Design Space.

DOPAMINE D3 RECEPTOR ANTAGONISTS HAVING A BICYCLO MOIETY

The disclosure provides compounds having formula (I), wherein the substituents are as defined herein. The compounds are useful for modulating the dopamine D3 receptor and for treating conditions associated therewith, such as addictions, drug dependency, and psychiatric conditions.

Novel morpholine scaffolds as selective dopamine (DA) D3 receptor antagonists

A new series of morpholine derivatives has been identified as selective DA D3 receptor antagonists; their in vitro profile and pharmacokinetic data are provided.