62348-24-7

Basic information

• Product Name: 4-METHYLOXAZOLE-5-CARBONYL CHLORIDE
• Synonyms: 4-METHYLOXAZOLE-5-CARBONYL CHLORIDE;5-Oxazolecarbonyl chloride, 4-methyl- (9CI);4-Methyl-1,3-oxazole-5-carbonyl chloride;4-Methyloxazole-5-carbonyl chloride ,97%;4-Methyl-1,3-oxazole-5-carbonyl chloride 97%;5-(Chlorocarbonyl)-4-methyl-1,3-oxazole, 5-(Chloroformyl)-4-methyl-1,3-oxazole;4-Methyl-1,3-oxazole-5-carbonylchloride97%
• CAS NO: 62348-24-7
• Molecular Formula: C₅H₄ClNO₂
• Molecular Weight: 145.54
• Product Categories: ACIDHALIDE
• Mol File: 62348-24-7.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 80 °C
• Flash Point: 72.6°C
• Appearance: /
• Density: 1.345g/cm³
• Vapor Pressure: 0.398mmHg at 25°C
• Refractive Index: 1.498
• CAS DataBase Reference: 4-METHYLOXAZOLE-5-CARBONYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-METHYLOXAZOLE-5-CARBONYL CHLORIDE(62348-24-7)
• EPA Substance Registry System: 4-METHYLOXAZOLE-5-CARBONYL CHLORIDE(62348-24-7)

Safety Data

• Hazard Codes: C
• Statements: 14-34
• Safety Statements: 22-26-36/37/39-45
• RIDADR: 3265
• Hazardous Substances Data: 62348-24-7(Hazardous Substances Data)

Usage

Chemical Properties

Colourless liquid

InChI:InChI=1/C5H4ClNO2/c1-3-4(5(6)8)9-2-7-3/h2H,1H3

Upstream product

• 20485-39-6 ethyl 4-methyloxazole-5-carboxylate 
• 2510-32-9 4-methyl-1,3-oxazole-5-carboxylic acid 

Downstream Products

• 87205-06-9 N-(3-butenyl)-4-methyl-N-phenyloxazole-5-carboxamide 
• 1159703-22-6 C₁₁H₁₃NO₃ 
• 87205-05-8 10-methyl-2-oxo-3-phenyl-11-oxa-3,9-diazatricyclo<6.2.1.0>undec-9-ene 
• 87205-04-7 8-methyl-1-oxo-2-phenylpiperidino<3,4-c>pyridine 
• 911297-49-9 6-[2-(4-methyl-oxazole-5-carbonyl)-phenyl]-hept-2-en-4-ynoic acid ethyl ester 
• 911297-48-8 (4-methyl-oxazol-5-yl)-[2-(1-methyl-prop-2-ynyl)-phenyl]methanone 
• 911297-36-4 (4-methyl-oxazol-5-yl)-[2-(1-methyl-3-trimethylsilanyl-prop-2-ynyl)-phenyl]methanone 
• 170959-55-4 1-(4-methyloxazole-5-carboxyl)-4-phenylthiosemicarbazide 
• 90620-25-0 N-allyl-4-methyloxazole-5-carboxamide 
• 90620-28-3 4-Methyl-oxazole-5-carboxylic acid ((E)-but-2-enyl)-phenyl-amide 
• 90620-27-2 N-allyl-4-methyloxazole-N-phenyl-5-carboxamide 
• 101708-13-8 5-hydroxy-4-hydroxymethyl-6-methylpyrimidine 
• 170959-39-4 3-(4-methyl-5-oxazoyl)-4-phenyl-5-methylthio-4H-1,2,4-triazole 
• 170959-47-4 5-(4-methyl-5-oxazoyl)-4-phenyl-2,4-dihydro-3H-1,2,4-triazole-3-thione 

Relevant articles and documents

Method for synthesizing furanosteroids

The present invention is a method for synthesizing furanosteroids. The method involves intramolecular Diels-Alder/retro-Diels-Alder reaction and tautomerization of a functionalized alkyne oxazole to produce a furo[2,3-b]phenol derivative which is elaborated by intermolecular and intramolecular condensations to generate ring-A of the furanosteroid. Furanosteroids and pharmaceutical compositions containing the same are also provided.

Oxazole to Pyrimidine Ring Transformation: Synthesis of Potential Pyridoxine Antagonists

The reaction of 4-methyloxazole-5-carbonyl chloride (I) with diazomethane gives 5-diazoacetyl-4-methyloxazole (II).Decomposition of II in methanol containing BF3-etherate provides the α-keto ether, 5-(methoxyacetyl)-4-methyloxazole (III).The α-ketol 5-(hydroxyacetyl)-4-methyloxazole (IV), obtained by decomposition of II in aq. acid, on treatment with dihydropyran in the presence of pyridinium toluene-p-sulfonate furnishes 4-methyl-5-oxazole (V).Warming III and V in methanolic ammonia in a sealed tube provides 5-hydroxy-4-methoxymethyl-6-methylpyrimidine (VI) and 5-hydroxy-6-methyl-4pyrimidine (VII), respectively.Acid-catalysed removal of the tetrahydropyranyl moiety from VII affords 5-hydroxy-4-hydroxymethyl-6-methylpyrimidine (VIII).