1710-62-9

Basic information

• Product Name: 5-(2-BROMOETHOXY)-2,3-DIHYDRO-1,4-BENZODIOXINE
• Synonyms: 5-(2-Bromoethoxy)-2,3-dihydro-1,4-benzodioxine97%;5-(2-BROMOETHOXY)-1,4-BENZODIOXANE;5-(2-BROMOETHOXY)-2,3-DIHYDRO-1,4-BENZODIOXINE;5-(2-Bromoethoxy)-1,4-benzodioxane, beta-Bromo-2,3-(ethylenedioxy)phenetole;5-(2-Bromoethoxy)-2,3-dihydro-1,4-benzodioxine 97%;5-(2-Bromo-ethoxy)-2,3-dihydro-benzo[1,4]dioxine;8-(2-bromoethoxy)-2,3-dihydro-1,4-benzodioxine
• CAS NO: 1710-62-9
• Molecular Formula: C10H11BrO3
• Molecular Weight: 259.1
• Mol File: 1710-62-9.mol
• Article Data: 3

Chemical Properties

• Melting Point: 85°C
• Boiling Point: 325.1 °C at 760 mmHg
• Flash Point: 131.6 °C
• Appearance: /
• Density: 1.506 g/cm³
• Vapor Pressure: 0.000446mmHg at 25°C
• Refractive Index: 1.565
• CAS DataBase Reference: 5-(2-BROMOETHOXY)-2,3-DIHYDRO-1,4-BENZODIOXINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(2-BROMOETHOXY)-2,3-DIHYDRO-1,4-BENZODIOXINE(1710-62-9)
• EPA Substance Registry System: 5-(2-BROMOETHOXY)-2,3-DIHYDRO-1,4-BENZODIOXINE(1710-62-9)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39-37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 1710-62-9(Hazardous Substances Data)

Usage

General Description

5-(2-Bromoethoxy)-2,3-dihydro-1,4-benzodioxine is a chemical compound with the molecular formula C10H11BrO3. It is a heterocyclic compound that contains a benzodioxine ring and a bromoethoxy group. This chemical is often used in the pharmaceutical industry as a building block for the synthesis of various biologically active compounds. It has also been studied for its potential as a drug candidate for various medical applications. However, like all chemical compounds, it should be handled with care and used in accordance with proper safety guidelines.

InChI:InChI=1/C10H11BrO3/c11-4-5-12-8-2-1-3-9-10(8)14-7-6-13-9/h1-3H,4-7H2

Upstream product

• 10288-36-5 2,3-dihydro-1,4-benzodioxin-5-ol 
• 106-93-4 ethylene dibromide 

Downstream Products

• 1459261-59-6 2-(2,3-dihydro-1,4-benzodioxin-5-yloxy)-N-metyl-N-(3-nitrobenzyl)ethylamine 
• 32604-73-2 2-(2,3-dihydrobenzo[1,4]dioxin-5-yloxy)-ethylamine 

Relevant articles and documents

Discovery of Novel pERK1/2- or β-Arrestin-Preferring 5-HT1AReceptor-Biased Agonists: Diversified Therapeutic-like versus Side Effect Profile

Novel 1-(1-benzoylpiperidin-4-yl)methanamine derivatives with high affinity and selectivity for serotonin 5-HT1A receptors were obtained and tested in four functional assays: ERK1/2 phosphorylation, adenylyl cyclase inhibition, calcium mobilization, and β-arrestin recruitment. Compounds 44 and 56 (2-methylaminophenoxyethyl and 2-(1H-indol-4-yloxy)ethyl derivatives, respectively) were selected as biased agonists with highly differential "signaling fingerprints"that translated into distinct in vivo profiles. In vitro, 44 showed biased agonism for ERK1/2 phosphorylation and, in vivo, it preferentially exerted an antidepressant-like effect in the Porsolt forced swimming test in rats. In contrast, compound 56 exhibited a first-in-class profile: it preferentially and potently activated β-arrestin recruitment in vitro and potently elicited lower lip retraction in vivo, a component of "serotonergic syndrome". Both compounds showed promising developability properties. The presented 5-HT1A receptor-biased agonists, preferentially targeting various signaling pathways, have the potential to become drug candidates for distinct central nervous system pathologies and possessing accentuated therapeutic activity and reduced side effects.

Heterocyclic compounds

The invention relates to compound of general formula (I): STR1 wherein: Z represents O or CH 2n is from 0 to 4R, X and Y are as defined in the description, andA represents STR2 wherein R 1, R 2, R 6, R 7 and T'' are as defined in the description,and medicinal products containing the same are useful in treating or in preventing melatoninergic disorders.