171002-19-0

Usage

Uses

Used in Pharmaceutical Industry:
3-(2-phenylacetaMido)-3-(4-chlorophenyl)propanoic acid is used as an analgesic for its pain-relieving properties, offering relief to patients suffering from various types of discomfort and pain.
3-(2-phenylacetaMido)-3-(4-chlorophenyl)propanoic acid is used as an anti-inflammatory agent to reduce inflammation in conditions such as arthritis, sprains, and other inflammatory disorders.
3-(2-phenylacetaMido)-3-(4-chlorophenyl)propanoic acid is used as an antipyretic to lower fever, helping to regulate body temperature in cases of elevated thermal response.
While the provided materials do not specify other industries or additional uses, the primary applications of 3-(2-phenylacetaMido)-3-(4-chlorophenyl)propanoic acid are within the pharmaceutical industry for its therapeutic effects on pain, inflammation, and fever. If there are other applications or industries where 3-(2-phenylacetaMido)-3-(4-chlorophenyl)propanoic acid is utilized, they would need to be specified in the materials provided.

Upstream product

• 19947-39-8 3-amino-3-(4-chlorophenyl)propionic acid 
• 103-80-0 phenylacetyl chloride 
• 104-88-1 4-chlorobenzaldehyde 

Downstream Products

• 131690-61-4 (R)-β-amino-β-(4-chlorophenyl)propionic acid 
• 171002-22-5 (S)-β-(N-phenylacetylamino)-β-(4-chlorophenyl)propionic acid 
• 131690-60-3 (S)-β-amino-β-(4-chlorophenyl)propionic acid 

Relevant academic research and scientific papers

Enantioselective acylation of β-phenylalanine acid and its derivatives catalyzed by penicillin G acylase from alcaligenes faecalis

This study developed a simple, efficient method for producing racemic β-phenylalanine acid (BPA) and its derivatives via the enantioselective acylation catalyzed by the penicillin G acylase from Alcaligenes faecalis (Af-PGA). When the reaction was run at 25°C and pH 10 in an aqueous medium containing phenylacetamide and BPA in a molar ratio of 2:1, 8 U/mL enzyme and 0.1 M BPA, the maximum BPA conversion efficiency at 40 min only reached 36.1%, which, however, increased to 42.9% as the pH value and the molar ratio of phenylacetamide to BPA were elevated to 11 and 3:1, respectively. Under the relatively optimum reaction conditions, the maximum conversion efficiencies of BPA derivatives all reached about 50% in a relatively short reaction time (45-90 min). The enantiomeric excess value of product (eep) and enantiomeric excess value of substrate (ees) were all above 98% and 95%, respectively. These results suggest that the method established in this study is practical, effective, and environmentally benign and may be applied to industrial production of enantiomerically pure BPA and its derivatives.

Biocatalytic approach to enatiomerically pure β-amino acids

β-Aryl-β-amino acids were prepared in good chemical yield and high enantiomeric purity (> 95% ee) via penicillin acylase-catalyzed hydrolysis of the corresponding N-phenylacetyl derivatives. The (R)-enantiomers were the fast-reacting isomers in all cases studied. The biocatalytic procedure described employs a very simple set of reactions using inexpensive commercially available chemicals and enzyme, and could be easily scaled up.