171002-19-0

Basic information

• Product Name: 3-(2-phenylacetaMido)-3-(4-chlorophenyl)propanoic acid
• Synonyms: 3-(2-phenylacetaMido)-3-(4-chlorophenyl)propanoic acid;3-(4-Chlorophenyl)-3-(2-phenylacetaMido)propanoic acid;4-Chloro-beta-[(2-phenylacetyl)amino]benzenepropanoic acid
• CAS NO: 171002-19-0
• Molecular Formula: C₁₇H₁₆ClNO₃
• Molecular Weight: 317.76684
• Mol File: 171002-19-0.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Density: 1.293
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-(2-phenylacetaMido)-3-(4-chlorophenyl)propanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-phenylacetaMido)-3-(4-chlorophenyl)propanoic acid(171002-19-0)
• EPA Substance Registry System: 3-(2-phenylacetaMido)-3-(4-chlorophenyl)propanoic acid(171002-19-0)

Safety Data

• Hazardous Substances Data: 171002-19-0(Hazardous Substances Data)

Usage

General Description

3-(2-phenylacetaMido)-3-(4-chlorophenyl)propanoic acid is a chemical compound that belongs to the class of nonsteroidal anti-inflammatory drugs (NSAIDs). It is primarily used to relieve pain, reduce inflammation, and lower fever. This chemical is structurally related to other NSAIDs such as ibuprofen and naproxen, and it works by inhibiting the production of prostaglandins, which are responsible for causing pain and inflammation in the body. However, it is important to note that this compound can have potential side effects, including gastrointestinal irritation, ulcers, and an increased risk of cardiovascular events. Therefore, it should be used with caution and under the guidance of a healthcare professional.

Upstream product

• 104-88-1 4-chlorobenzaldehyde 
• 19947-39-8 3-amino-3-(4-chlorophenyl)propionic acid 
• 103-80-0 phenylacetyl chloride 

Downstream Products

• 131690-60-3 (S)-β-amino-β-(4-chlorophenyl)propionic acid 
• 171002-22-5 (S)-β-(N-phenylacetylamino)-β-(4-chlorophenyl)propionic acid 
• 131690-61-4 (R)-β-amino-β-(4-chlorophenyl)propionic acid 

Relevant articles and documents

Enantioselective acylation of β-phenylalanine acid and its derivatives catalyzed by penicillin G acylase from alcaligenes faecalis

This study developed a simple, efficient method for producing racemic β-phenylalanine acid (BPA) and its derivatives via the enantioselective acylation catalyzed by the penicillin G acylase from Alcaligenes faecalis (Af-PGA). When the reaction was run at 25°C and pH 10 in an aqueous medium containing phenylacetamide and BPA in a molar ratio of 2:1, 8 U/mL enzyme and 0.1 M BPA, the maximum BPA conversion efficiency at 40 min only reached 36.1%, which, however, increased to 42.9% as the pH value and the molar ratio of phenylacetamide to BPA were elevated to 11 and 3:1, respectively. Under the relatively optimum reaction conditions, the maximum conversion efficiencies of BPA derivatives all reached about 50% in a relatively short reaction time (45-90 min). The enantiomeric excess value of product (eep) and enantiomeric excess value of substrate (ees) were all above 98% and 95%, respectively. These results suggest that the method established in this study is practical, effective, and environmentally benign and may be applied to industrial production of enantiomerically pure BPA and its derivatives.