171002-25-8

Usage

Uses

Used in Pharmaceutical Synthesis:
(3R)-3-AMINO-3-(3,4,5-TRIMETHOXYPHENYL)PROPANOIC ACID is used as a key intermediate in the synthesis of various pharmaceuticals for its unique structural features and potential therapeutic activity.
Used in Organic Chemistry:
(3R)-3-AMINO-3-(3,4,5-TRIMETHOXYPHENYL)PROPANOIC ACID is utilized as a building block in organic chemistry for the creation of complex organic molecules, taking advantage of its reactive functional groups and structural diversity.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, (3R)-3-AMINO-3-(3,4,5-TRIMETHOXYPHENYL)PROPANOIC ACID is used as a precursor for the development of new pharmaceuticals, given its potential to contribute to the discovery of novel therapeutic agents with improved efficacy and selectivity.

Upstream product

• 141-82-2 malonic acid 
• 86-81-7 3,4,5-trimethoxy-benzaldehyde 
• 34841-00-4 β-amino-β-(3,4,5-trimethoxyphenyl)propionic acid 

Relevant academic research and scientific papers

BETA-AMINO ACID DERIVATIVES FOR TREATMENT OF DIABETES

Novel heterocyclic compounds of the Formula (I) in which R1, R2, R2', R2', R3, R4, R5, R6, R7 and R8 have the meanings indicated in Claim 1, are activators of glucokinase and can be used for the prevention and/or treatment of Diabetes Typ 1 and 2, obesity, neuropathy and/or nephropathy.

Competitive formation of β-amino acids, propenoic, and ylidenemalonic acids by the Rodionov reaction from malonic acid, aldehydes, and ammonium acetate in alcoholic medium

The Rodionov reaction of 49 available aliphatic and aromatic aldehydes with malonic acid and ammonium acetate in alcoholic medium, resulting in formation of β-amino acids, propenoic, and ylidenemalonic acids, was studied. Certain regioselectivity regularities of the reaction were revealed. Among the variety of ketones studied, cyclohexanone is the only whose reaction yields a β-amino acid. Unusual dehydrofluorination of 6-chloro-2-fluorocinnamic acid under the Rodionov reaction was discovered. 2005 Pleiades Publishing, Inc.

Biocatalytic approach to enatiomerically pure β-amino acids

β-Aryl-β-amino acids were prepared in good chemical yield and high enantiomeric purity (> 95% ee) via penicillin acylase-catalyzed hydrolysis of the corresponding N-phenylacetyl derivatives. The (R)-enantiomers were the fast-reacting isomers in all cases studied. The biocatalytic procedure described employs a very simple set of reactions using inexpensive commercially available chemicals and enzyme, and could be easily scaled up.

Effective cerebral antihypoxic activity of new aminocyclopentanones

Effective antihypoxic activity of new aminocyclopentanones which was higher than that of the reference compounds has been demonstrated by the SCR hypoxia test.

One-Pot Cyclization of Alkoxy-3-Aminoindan-1-ones.

3-Amino-3-alkoxyphenylpropionic acids, prepared from alkoxybenzaldehydes, are cyclized in one step into 3-aminoindan-1-ones using trifluoroacetic acid and trifluoroacetic anhydride. Key Words: One-pot cyclization; Aminoindanones; Electrodonating substitue