34841-00-4Relevant academic research and scientific papers
BETA-AMINO ACID DERIVATIVES FOR TREATMENT OF DIABETES
-
Page/Page column 51, (2009/09/05)
Novel heterocyclic compounds of the Formula (I) in which R1, R2, R2', R2', R3, R4, R5, R6, R7 and R8 have the meanings indicated in Claim 1, are activators of glucokinase and can be used for the prevention and/or treatment of Diabetes Typ 1 and 2, obesity, neuropathy and/or nephropathy.
Competitive formation of β-amino acids, propenoic, and ylidenemalonic acids by the Rodionov reaction from malonic acid, aldehydes, and ammonium acetate in alcoholic medium
Lebedev,Lebedeva,Sheludyakov,Kovaleva,Ustinova,Kozhevnikov
, p. 1113 - 1124 (2007/10/03)
The Rodionov reaction of 49 available aliphatic and aromatic aldehydes with malonic acid and ammonium acetate in alcoholic medium, resulting in formation of β-amino acids, propenoic, and ylidenemalonic acids, was studied. Certain regioselectivity regularities of the reaction were revealed. Among the variety of ketones studied, cyclohexanone is the only whose reaction yields a β-amino acid. Unusual dehydrofluorination of 6-chloro-2-fluorocinnamic acid under the Rodionov reaction was discovered. 2005 Pleiades Publishing, Inc.
Effective cerebral antihypoxic activity of new aminocyclopentanones
Quermonne,Dallemagne,Louchahi-Raoul,Pilo,Rault,Robba
, p. 961 - 965 (2007/10/02)
Effective antihypoxic activity of new aminocyclopentanones which was higher than that of the reference compounds has been demonstrated by the SCR hypoxia test.
One-Pot Cyclization of Alkoxy-3-Aminoindan-1-ones.
Dallemagne, Patrick,Rault, Sylvain,Pilo, Juan Carlos,Foloppe, Marie Paule,Robba, Max
, p. 6327 - 6328 (2007/10/02)
3-Amino-3-alkoxyphenylpropionic acids, prepared from alkoxybenzaldehydes, are cyclized in one step into 3-aminoindan-1-ones using trifluoroacetic acid and trifluoroacetic anhydride. Key Words: One-pot cyclization; Aminoindanones; Electrodonating substitue
