171013-49-3

Upstream product

• 58479-61-1 tert-butylchlorodiphenylsilane 
• 180628-76-6 3-Benzenesulfonylmethyl-5-nitro-phenol 
• 78238-12-7 3-methoxy-5-nitrobenzoic acid 
• 99-34-3 3,5-dinitrobenzoic acid 
• 180628-75-5 3-Bromomethyl-5-nitro-phenol 
• 180628-74-4 3-hydroxy-5-nitrobenzyl alcohol 
• 78238-14-9 3-hydroxy-5-nitrobenzoic acid 

Downstream Products

• 171013-50-6 (3-benzenesulfonylmethyl-5-tert-butyldiphenylsilyloxy)aniline 
• 171013-69-7 (R)-4-Hydroxy-N-(3-hydroxy-5-{(Z)-4-[(4R,5S,6S)-6-(2-hydroxy-ethyl)-2,2,5-trimethyl-[1,3]dioxan-4-yl]-pent-3-enyl}-phenyl)-3-methoxy-N-(2,2,2-trichloro-ethoxymethyl)-butyramide 
• 171013-51-7 (R)-N-[3-Benzenesulfonylmethyl-5-(tert-butyl-diphenyl-silanyloxy)-phenyl]-4-hydroxy-3-methoxy-butyramide 
• 180628-87-9 (R)-N-(3-Hydroxy-5-{(Z)-4-[(4R,5S,6S)-2,2,5-trimethyl-6-(2-oxo-ethyl)-[1,3]dioxan-4-yl]-pent-3-enyl}-phenyl)-3-methoxy-4-oxo-N-(2,2,2-trichloro-ethoxymethyl)-butyramide 
• 171013-52-8 (R)-N-[3-Benzenesulfonylmethyl-5-(tert-butyl-diphenyl-silanyloxy)-phenyl]-4-(tert-butyl-dimethyl-silanyloxy)-3-methoxy-butyramide 
• 171013-67-5 (R)-4-(tert-Butyl-dimethyl-silanyloxy)-N-[3-((Z)-4-{(4R,5S,6S)-6-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-pent-3-enyl)-5-(tert-butyl-diphenyl-silanyloxy)-phenyl]-3-methoxy-butyramide 
• 171013-68-6 C₅₆H₈₈Cl₃NO₈Si₃ 

Relevant academic research and scientific papers

Synthesis of an Advanced Fragment of (+)-Trienomycinol

The synthesis of the fully functionalized eastern fragment of trienomycins A-F, ansamycin antibiotics is described. A key step involves a peptidic coupling between a sulfonyl aniline and an enantiopure carboxylic acid obtained by a completely diastereosel

Total syntheses of (+)-trienomycins A and F via a unified strategy

The first total syntheses of (+)-trienomycins A and F, representative members of a new class of cytotoxic ansamycin antibiotics, have been achieved. Key features of the unified synthetic scheme included incorporation of the (E,E,E)-triene unit with concom