171016-63-0Relevant academic research and scientific papers
Carboxylate-Assisted Oxidative Addition to Aminoalkyl PdII Complexes: C(sp3)?H Arylation of Alkylamines by Distinct PdII/PdIV Pathway
Whitehurst, William G.,Blackwell, J. Henry,Hermann, Gary N.,Gaunt, Matthew J.
supporting information, p. 9054 - 9059 (2019/06/04)
Reported is the discovery of an approach to functionalize secondary alkylamines using 2-halobenzoic acids as aryl-transfer reagents. These reagents promote an unusually mild carboxylate-assisted oxidative addition to alkylamine-derived palladacycles. In the presence of AgI salts, a decarboxylative C(sp3)?C(sp2) bond reductive elimination leads to γ-aryl secondary alkylamines and renders the carboxylate motif a traceless directing group. Stoichiometric mechanistic studies were effectively translated to a Pd-catalyzed γ-C(sp3)?H arylation process for secondary alkylamines.
A concise synthesis of arnottin I via internal biaryl coupling reaction using palladium reagent
Harayama, Takashi,Yasuda, Hirotake
, p. 61 - 64 (2007/10/03)
Total synthesis of arnottin I (1) was accomplished via the internal arylaryl coupling reaction of iodo-ester (2) by the palladium-assisted cyclization reaction.
A Direct Route to the Pyrrolobenzodiazepine Ring System Using Aryl Triflates
Kraus, George A.,Liu, Peng
, p. 7595 - 7598 (2007/10/02)
The pyrrolobenzodiazepine and dibenzodiazepine skeletons were rapidly generated from salicylic acids.The key step in these syntheses was the substitution of an aryl triflate.
