17103-76-3

Upstream product

• 1132-21-4 3,5-dimethoxybenzoic acid 
• 2150-37-0 methyl 3,5-dimethoxybenzoate 
• 7311-34-4 3,5-dimethoxybenzaldehdye 
• 20469-65-2 1-bromo-3,5-dimethoxybenzene 
• 106675-70-1 N¹,N²-dimethoxy-N¹,N²-dimethyloxalamide 
• 144758-76-9 1,2-bis-(3,5-dimethoxyphenyl)-2-hydroxyethanone 

Downstream Products

• 162407-06-9 2,3-bis(3,5-dimethoxyphenyl)-1,4-diazaspiro[4.5]deca-1,3-diene 
• 144758-76-9 1,2-bis-(3,5-dimethoxyphenyl)-2-hydroxyethanone 
• 1313574-90-1 3,3',5,5'-tetra(decyloxy)benzil 
• 1310094-15-5 (1,2-bis(3,5-dihydroxyphenyl)ethane-1,2-dione) 

Relevant academic research and scientific papers

Preparation method of natural product resveratrol dimer diphosphate derivative

The invention belongs to the technical field of chemical synthesis, and particularly relates to a preparation method of a natural product resveratrol dimer diphosphate derivative. The method comprises the following steps: performing two-step condensation

Isopaucifloral F phosphate ester compound and medicinal application thereof

The invention belongs to the technical field of biological medicines, and relates to an Isopaucifloral F phosphate ester compound and a medicinal application thereof. Experiments prove that the Isopaucifloral F phosphate ester compound and pharmaceuticall

Discovery of novel sesquistilbene indanone analogues as potent anti-inflammatory agents

To develop novel anti-inflammatory agents with improved pharmaceutical profiles, twenty-eight novel sesquistilbene indanone analogues were synthesized and evaluated for anti-inflammatory activity using RAW264.7 cells. Among these compounds, compound 11k was found to be one of the most potent analogues in inhibiting NO production in LPS-stimulated RAW264.7 cells. Furthermore, it could also significantly suppress LPS-induced iNOS and COX-2 expression and NO production through TLR4/JNK/NF-κB signaling pathway in a concentration dependent manner.

Synthesis, estrogenic activity, and anti-osteoporosis effects in ovariectomized rats of resveratrol oligomer derivatives

Three series of resveratrol oligomer derivatives were synthesized, including the indenone-type, indene-type and octahydropentalene-type derivatives, among which ten derivatives were novel compounds. Compounds 2, 14f, and 4d were confirmed as ERβ agonists

Synthesis and biological evaluation of novel neuroprotective agents for paraquat-induced apoptosis in human neuronal SH-SY5Y cells

Three types of resveratrol analogues were designed, synthesized and evaluated in vitro against paraquat-induced apoptosis in SH-SY5Y cells. The results showed that some compounds, especially those containing an indene core, exhibit good activities. Analogue 3′a showed a potent neuroprotective effect at a low concentration (10 μM). Further investigation showed that compound 3′a could attenuate paraquat-induced nuclear morphological changes, significantly decrease paraquat-induced ROS (reactive oxygen species) generation in SH-SY5Y cells and elevate the expression of SOD (Superoxide Dismutase) and GPx (glutathione peroxidase) in a dose-dependent manner. Furthermore, analogue 3′a could decrease Bax protein levels in a concentration-dependent manner and increase Bcl-2 protein expression, which was accompanied by increasing chances of cell survival.

Inhibitory effect of resveratrol dimerized derivatives on nitric oxide production in lipopolysaccharide-induced RAW 264.7 cells

Four types of resveratrol dimerized analogues were synthesized and evaluated in vitro on LPS-induced NO production in RAW 264.7 cells. The results showed that several compounds, especially those containing 1,2-diphenyl-2,3- dihydro-1H-indene core (type I), exhibited good inhibitory activities. Among 25 analogues, 12b showed a significant inhibitory activity (49% NO production at 10 μM, IC50 = 3.38 μM). Further study revealed that compound 12b could suppress LPS-induced iNOS expression, NO production, and IL-1β release in a concentration-dependently manner. The mechanism of action (MOA) involved for its anti-inflammatory responses was through signaling pathways of p38 MAPK and JNK1/2, but not ERK1/2.

Discotic nickel bis(dithiolene) complexes - Synthesis, optoelectrochemical and mesomorphic properties

Fifteen neutral long-chain-substituted discotic nickel bis(1,2-diphenyl-1, 2-ethenedithiolene) complexes [Ni(dpedt)2], including thirteen new compounds, have been synthesized by new short and efficient synthetic pathways. Physical investigations show that these complexes are thermally stable, possess good electron-accepting properties, and absorb light strongly in the near-infrared spectral region. Electrochemical and optical properties of [Ni(dpedt)2] depend moderately on the functionalities attached to the phenyl rings of the complexes. Their LUMO and HOMO energy levels are in the range -4.7 to -5.0 and -5.7 to -6.0 eV, respectively. Two octa(n-alkoxy)- substituted complexes exhibit a columnar liquid crystalline phase with hexagonal symmetry. These highly soluble complexes are potential candidates for use as electron-accepting and electron-transporting materials for active layers in organic electronic applications, such as field-effect transistors or photovoltaic devices. Electrochemical and optical studies as well as multiphase transition behavior are reported for a series of new nickel bis(dithiolene) complexes. The effects of the nature and position of the functional groupsattached to the periphery of the complexes are investigated. X-ray diffraction measurements regarding the hexagonal columnar mesophase are reported. Copyright

Concise total syntheses of (±)isopaucifloral F, (±) quadrangularin A, and (±)pallidol

Concise total syntheses of (±)isopaucifloral F, (±) quadrangularin A, and (±)pallidol, starting from commercially available 3,5-dimethoxybenzoic acid, have been achieved by a sequential process. The overall synthetic strategy involves Nazarov cyclization, Ramberg-Backlund olefination, and Friedel-Crafts alkylation. Crown Copyright

Synthesis of an enantiopure fluorous 1,2-diphenyl-1,2-diaminoethane

Enantiopure fluorous 1,2-diphenyl-1,2-ethanediamine bearing four fluorous ponytails and having 62.2% fluorine content has been prepared. Resolution of racemic 1,2-bis(3,5-dimethoxyphenyl)ethane-1,2-diamine with (-)-menthyl chloroformate followed by reduct

Photogeneration of amines from α-keto carbamates: Design and preparation of photoactive compounds

The design and synthesis of substituted desyl (2-oxo-1,2-diphenylethyl) groups has been investigated to create new photolabile protecting groups. The photoreactivity of these chromophores stems from the diverse photochemistry of the desyl group. Several chromophore designs have been explored in which the substitution pattern of the parent desyl chromophore was varied systematically. The required benzoin chromophores are prepared by a variety of synthetic routes, depending on the structure of the benzoin chromophore desired. Symmetrical benzoins are readily available via the benzoin condensation. Unsymmetrical benzoins including 2,2-disubstituted α-hydroxy ketones are generally prepared via trimethylsilyl (TMS) masked cyanohydrins. On reaction with a Grignard reagent, the TMS masked cyanohydrin functions as an α-hydroxycarbonyl equivalent to form α-hydroxy ketones. Alternatively, lithiation of a TMS masked cyanohydrin generates a benzoyl anion equivalent which reacts with aldehydes and ketones to generate substituted benzoins. These desyl chromophores have significant potential as new photolabile protecting moieties for a variety of functional groups and are used to mask primary and secondary amines as photosensitive α-keto carbamates. The substituted benzoin carbamates are readily prepared from the appropriate benzoin by reaction with isocyanates or by activation as a mixed carbonate followed by reaction with the free amine. These α-keto carbamates are interesting for two main reasons. First, the facile synthesis of these materials indicates the ease of introduction of the desyl based photolabile group. Second, these α-keto carbamates may be used for rapid evaluation of novel photoactive desyl based chromophores.