171031-89-3Relevant academic research and scientific papers
Synthesis and α-mannosidase inhibitory activity of three deoxy derivatives of mannostatin A
Ogawa, Seiichiro,Morikawa, Takayuki
, p. 1759 - 1765 (2007/10/03)
Three deoxy derivatives 2-4 of the α-mannosidase inhibitor mannostatin A (1) were synthesized, and their inhibition of Jack bean α-mannosidase was evaluated in order to elucidate the roles of each of the three hydroxyl groups of the inhibitor. The 1- and 2-deoxy derivatives 2 and 3 retained some inhibitory activity, although reduced by a factor of about 100 relative to the parent, whereas it was completely lost with the 3-deoxy derivative 4. Structure and activity relationships are discussed in the light of these findings.
Synthesis and biological evaluation of α-mannosidase inhibitory activity of three deoxy derivatives of mannostatin A
Ogawa, Seiichiro,Morikawa, Takayuki
, p. 1499 - 1504 (2007/10/03)
Three deoxy derivatives of α-mannosidase inhibitor mannostatin A have been synthesized and their inhibitory activity for Jack beans α-mannosidase evaluated in order to elucidate roles of each hydroxyl groups of the inhibitor. The 1- and 2-deoxy derivatives have preserved inhibitory potentials although they lowered the activity one-hundred fold compared to the parent, but the 3-deoxy derivative lost activity.
Preparation of optically active derivatives of (1,4/2,3,5)- and (1,2,3,4,5/0)-5-aminocyclopentane-1,2,3,4-tetraols: synthesis of mannostatin A and its enantiomer
Ogawa, Seiichiro,Kimura, Hiroshi,Uchida, Chikara,Ohashi, Takashi
, p. 1695 - 1706 (2007/10/02)
Diastereoselective acylation of the 2,3-O-cyclohexanediyl derivatives of (1,4/2,3,5)- and (1,2,3,4,5/0)-5-acetamidocyclopentane-1,2,3,4-tetraols with some optically active chiral acids afforded, with moderate diastereoselectivity, the chiral monoesters useful as synthetic intermediates, from which mannostatin A and its enantiomer were synthesized.
