229306-00-7

Upstream product

• 7322-88-5 (S)-acetylmandelic acid 
• 61768-70-5 2,3-O-cyclohexylidene (1,2,3,4,5/0)-5-acetamido-1,2,3,4-cyclopentanetetrol 
• 171031-89-3 2,3-O-cyclohexylidene (1S,2R,3R,4R,5S)-5-acetamido-1-O-[(2S)-2-O-acetylmandelyl]-1,2,3,4-cyclohexanetetrol 

Downstream Products

• 229306-16-5 1,2-O-cyclohexylidene (1R,2R,3R,4S,5S)-5-acetamido-4-O-[(2S)-2-O-acetylmandelyl]-3-O-phenoxythiocarbonyl-1,2,3,4-cyclopentanetetrol 
• 229306-17-6 1,2-O-cyclohexylidene (1S,2R,3S,4R)-3-acetamido-4-O-[(2S)-2-O-acetylmandelyl]-1,2,4-cyclopentanetetrol 

Relevant academic research and scientific papers

Synthesis and α-mannosidase inhibitory activity of three deoxy derivatives of mannostatin A

Three deoxy derivatives 2-4 of the α-mannosidase inhibitor mannostatin A (1) were synthesized, and their inhibition of Jack bean α-mannosidase was evaluated in order to elucidate the roles of each of the three hydroxyl groups of the inhibitor. The 1- and 2-deoxy derivatives 2 and 3 retained some inhibitory activity, although reduced by a factor of about 100 relative to the parent, whereas it was completely lost with the 3-deoxy derivative 4. Structure and activity relationships are discussed in the light of these findings.