171037-01-7

Basic information

• Product Name: (R)-DIPHENYLALANINOL
• Synonyms: (R)-DIPHENYLALANINOL;(R)-2-AMino-3,3-diphenylpropan-1-ol
• CAS NO: 171037-01-7
• Molecular Formula: C₁₅H₁₇NO
• Molecular Weight: 227.3
• Mol File: 171037-01-7.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 410.0±40.0 °C(Predicted)
• Appearance: /
• Density: 1.113±0.06 g/cm3(Predicted)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 12.62±0.10(Predicted)
• CAS DataBase Reference: (R)-DIPHENYLALANINOL(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-DIPHENYLALANINOL(171037-01-7)
• EPA Substance Registry System: (R)-DIPHENYLALANINOL(171037-01-7)

Safety Data

• Hazardous Substances Data: 171037-01-7(Hazardous Substances Data)

Usage

General Description

(R)-Diphenylalaninol, also known as (R)-2-Amino-3-phenylpropan-1-ol, is a chiral alcohol compound with the molecular formula C9H13NO. It exists as a white solid at room temperature and has a molecular weight of 151.21 g/mol. (R)-Diphenylalaninol is often used as a chiral auxiliary in asymmetric synthesis and as a building block in the preparation of pharmaceutical compounds and natural product derivatives. It is also known for its potential as a ligand in catalysis and for its application in the synthesis of biologically active molecules. Additionally, (R)-Diphenylalaninol has been studied for its pharmacological properties, including its potential as an anti-cancer and anti-inflammatory agent. Overall, (R)-Diphenylalaninol is a versatile compound with a wide range of applications in organic chemistry and biochemistry.

Upstream product

• 71-43-2 benzene 
• 204851-53-6 (S)-4-Benzyl-3-((R)-2-hydroxymethyl-3,3-diphenyl-propionyl)-oxazolidin-2-one 
• 155836-48-9 tert-butyl [(2R)-3-hydroxy-1,1-diphenylpropan-2-yl]carbamate 
• 204851-65-0 (R)-2-Hydroxymethyl-3,3-diphenyl-propionic acid 
• 170937-75-4 (S)-N-tert-butoxycarbonyl-4-(hydroxydiphenylmethyl)-2,2-dimethyloxazolidine 

Downstream Products

• 176697-24-8 [(OCH₂CH(NH₂)CH(C₆H₅)2)Al(Si(CH₃)3)2]2 
• 176697-27-1 (OCH₂CH(NH₂)CH(C₆H₅)2)Al(CH₃)2Al(CH₃)3 
• 176697-22-6 [(OCH₂CH(NH₂)CH(C₆H₅)2)Al(CH₃)2]2 
• 270078-94-9 (R,R)-2,2'-isopropylidenebis(4-(diphenylmethyl)oxazoline) 
• 176697-23-7 [(OCH₂CH(NH₂)CH(C₆H₅)2)Al(C₂H₅)2]2 
• 270078-93-8 (R,R)-N,N'-bis(2-chloro-1-(diphenylmethyl)ethyl)-2,2-dimethylmalonamide 
• 270078-96-1 (R,R)-N,N'-bis[2-chloro-1-(diphenylmethyl)ethyl]oxamide 
• 944836-33-3 (R)-4-benzhydryl-2-(2-bromophenyl)-4,5-dihydrooxazole 
• 270078-95-0 (R,R)-N,N'-bis(1-diphenylmethyl-2-hydroxyethyl)oxamide 
• 155836-48-9 tert-butyl [(2R)-3-hydroxy-1,1-diphenylpropan-2-yl]carbamate 
• 1131379-93-5 C₂₂H₂₀INO₂ 

Relevant articles and documents

Reactions of amino alcohols in superacid: the direct observation of dicationic intermediates and their application in synthesis.

[reaction: see text]. The chemistry of amino alcohols has been studied in superacidic media, and these compounds have been found to ionize cleanly to the dication intermediates. Several dicationic species have been directly observed by low-temperature 13C NMR, including those from epinephrine (adrenaline) and synephrine. Amino alcohols react (70-99% yields) with C6H6 in triflic acid (CF3SO3H) by electrophilic aromatic substitution.

Bifunctional iminophosphorane organocatalysts for enantioselective synthesis: Application to the ketimine nitro-Mannich reaction

The design, synthesis, and development of a new class of modular, strongly basic, and tunable bifunctional Bronsted base/H-bond-donor organocatalysts are reported. These catalysts incorporate a triaryliminophosphorane as the Bronsted basic moiety and are readily synthesized via a last step Staudinger reaction of a chiral organoazide and a triarylphosphine. Their application to the first general enantioselective organocatalytic nitro-Mannich reaction of nitromethane to unactivated ketone-derived imines allows the enantioselective construction of β-nitroamines possessing a fully substituted carbon atom. The reaction is amenable to multigram scale-up, and the products are useful for the synthesis of enantiopure 1,2-diamine and α-amino acid derivatives.

Preparation of chiral oxazolidin-2-ones and vicinal amino alcohols

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