171045-79-7Relevant academic research and scientific papers
A simple stereoselective synthesis and biological evaluation of FR181157: Orally active prostacyclin mimetic
Hattori, Kouji,Tabuchi, Seiichiro,Okitsu, Osamu,Taniguchi, Kiyoshi
, p. 4277 - 4279 (2007/10/03)
Synthetic method of novel prostaglandin (PG) mimetic: FR181175 without PG skeleton are described. The key to success is creation of a chiral epoxide using Sharpless AD reaction with high ee yield. FR181157 shows high potency and agonist efficacy at the IP receptor and has good bioavailability.
