171075-02-8Relevant academic research and scientific papers
Alkylation of 6-N-acylated adenosine derivatives by the use of phase transfer catalysis
Aritomo, Keiichi,Wada, Takeshi,Sekine, Mitsuo
, p. 1837 - 1844 (2007/10/02)
6-N- or N1-Alkylation of 6-N-acyl adenosine derivatives with alkyl halides in CH2Cl2 - 1 mol dm-3 NaOH in the presence of Bu4NBr has been studied.A variety of N-acyl groups have been examined.Consequently, the use of the acetyl and 2-(trimethylsilyl)ethoxycarbonyl groups resulted in the corresponding 6-N-alkylated products in high yields.It was also found that, when the benzoyl group was chosen as the N-acyl group, N1-alkylated products were obtained along with 6-N-alkylated products were obtained along with 6-N-alkylated products.The structure of the 6-N- and N1-alkylated adenosine derivatives has been determined by 1H and 13C NMR spectroscopy.
