171082-91-0

Usage

Uses

Used in Pharmaceutical Industry:
1H-Benzimidazol-2-amine, 4-methyl(9CI) is used as a pharmaceutical compound for its antimicrobial and antifungal properties, making it a candidate for developing new drugs to combat infections caused by various microorganisms.
Used in Agricultural Industry:
In agriculture, 1H-Benzimidazol-2-amine, 4-methyl(9CI) is utilized as an antimicrobial and antifungal agent to protect crops from diseases and pests, thereby enhancing crop yield and quality.
Used in Material Science:
1H-Benzimidazol-2-amine, 4-methyl(9CI) serves as a building block in material science for the synthesis of other biologically active compounds, contributing to the development of new materials with specific properties and applications.

Upstream product

• 506-68-3 bromocyane 
• 2687-25-4 3-methyl-1,2-benzenediamine 

Relevant academic research and scientific papers

MRGX Receptor Antagonists

The invention relates to a method for preventing or treating a disease or disorder that is associated with the MrgX2 receptor. The invention also relates to MrgX2 antagonists and physiologically acceptable salts thereof. The invention also relates to pharmaceutical compositions and dosage forms comprising an MrgX2 antagonist.

Inhibition and Dispersion of Bacterial Biofilms with 2-Aminobenzimidazole Derivatives

Compounds described herein inhibit biofilm formation or disperse pre-formed biofilms of Gram-negative bacteria. Biofilm-inhibitory compounds can be encapsulated or contained in a polymer matrix for controlled release. Coatings, films, multilayer films, hydrogels, microspheres and nanospheres as well as pharmaceutical compositions and disinfecting compositions containing biofilm-inhibitory compounds are also provided. Methods for inhibiting formation of biofilms or dispersing already formed biofilms are provided. Methods for treating infections of gram-negative bacteria which form biofilms, particularly those of Pseudomonas and more particularly P. aeruginosa.

2-aminobenzimidazole derivatives strongly inhibit and disperse Pseudomonas aeruginosa biofilms

Bacterial biofilms are exceptionally difficult to clear using traditional antibiotics and constitute a significant health threat. 2-Aminobenzimidazole derivatives (see scheme) are capable of strongly inhibiting the growth of and dispersing Pseudomonas aeruginosa biofilms. These molecules were found to modulate quorum sensing in reporter strains, and represent some of strongest P. aeruginosa biofilm inhibitors known. Copyright

Catalyst-controlled chemoselective arylation of 2-aminobenzimidazoles

What N would you like? The chemoselective and complementary Pd- and Cu-catalyzed N-arylation of 2-aminobenzimidazoles is described. Selective N-arylation of the amino group was achieved with a Pd-catalyzed method, while selective N-arylation of azole nitrogen was achieved with a Cu-catalyzed procedure (see scheme). Copyright