171192-75-9

Upstream product

• 72289-52-2 (2S,4R)-4-hydroxy-1-phenylmethoxycarbonylpyrrolidine-2-carboxylic acid tert-butyl ester 
• 393154-87-5 ert-butyl 4-hydroxypyrrolidine-2-carboxylate 

Downstream Products

• 171336-74-6 (2S,4R)-1-benzyl-2-tert-butoxycarbonylpyrrolidine-4-spiro-5'-hydantoin 
• 171192-76-0 (2S,4S)-1-benzyl-2-tert-butoxycarbonylpyrrolidine-4-spiro-5'-hydantoin 
• 171192-78-2 methyl (2S,4S)-4-amino-1-benzyl-4-methoxycarbonylprolinate 
• 171336-82-6 methyl (2S,4R)-4-amino-1-benzyl-4-methoxycarbonylprolinate 
• 171336-75-7 (2S,4S)-4-amino-1-benzyl-4-carboxyproline 
• 171336-77-9 (2S,4R)-4-amino-1-benzyl-4-carboxyproline 
• 171336-79-1 (2S,4S)-4-amino-4-carboxyproline 
• 171336-79-1 (2S,4R)-4-aminopyrrolidine-2,4-dicarboxylic acid 

Relevant academic research and scientific papers

Asymmetric syntheses of all four isomers of 4-amino-4-carboxyproline: Novel conformationally restricted glutamic acid analogues

Asymmetric syntheses of all four isomers of 4-amino-4-carboxyprolines, i.e. (2S,4S)-3, (2S,4R)-4, and their corresponding enantiomers, as novel conformationally restricted analogues of glutamic acid, were performed from trans-4-hydroxy-L-proline as a homochiral starting material. The key step was the spirohydantoin ring formation by employing the Bucherer-Bergs reaction of 4-oxoproline derivatives. These structures were determined by NMR studies.