171336-75-7Relevant academic research and scientific papers
Synthesis and metabotropic glutamate receptor antagonist activity of N1-substituted analogs of 2R,4R-4-aminopyrrolidine-2,4-dicarboxylic acid
Valli, Matthew J.,Schoepp, Darryle D.,Wright, Rebecca A.,Johnson, Bryan G.,Kingston, Ann E.,Tomlinson, Rosemarie,Monn, James A.
, p. 1985 - 1990 (2007/10/03)
A series of N1-substituted derivatives of (2R,4R)-4-aminopyrrolidine- 2,4-dicarboxylate (2R,4R-APDC) has been prepared as constrained analogs of γ-substituted glutamic acids and examined for their effects at recombinant metabotropic glutamate receptor (mGluR) subtypes in vitro. Appropriate substitution of the N1 position of 2R,4R-APDC resulted in the identification of a number of selective group II mGluR antagonists.
Asymmetric syntheses of all four isomers of 4-amino-4-carboxyproline: Novel conformationally restricted glutamic acid analogues
Tanaka,Sawanishi
, p. 1641 - 1656 (2007/10/02)
Asymmetric syntheses of all four isomers of 4-amino-4-carboxyprolines, i.e. (2S,4S)-3, (2S,4R)-4, and their corresponding enantiomers, as novel conformationally restricted analogues of glutamic acid, were performed from trans-4-hydroxy-L-proline as a homochiral starting material. The key step was the spirohydantoin ring formation by employing the Bucherer-Bergs reaction of 4-oxoproline derivatives. These structures were determined by NMR studies.
