171348-52-0Relevant articles and documents
Iron(II)-catalyzed intramolecular olefin aminofluorination
Lu, Deng-Fu,Liu, Guan-Sai,Zhu, Cheng-Liang,Yuan, Bo,Xu, Hao
, p. 2912 - 2915 (2014/06/23)
An iron(II)-catalyzed diastereoselective olefin aminofluorination is reported (dr up to >20:1). This new transformation applies a functionalized hydroxylamine and Et3N·3HF as the nitrogen and fluorine source, which facilitates the efficient synthesis of β-fluoro primary amines and amino acids from allylic alcohol derivatives. Preliminary mechanistic studies reveal that an iron-nitrenoid is a possible intermediate and that its reactivity and enantioselectivity can be efficiently modulated by ligands.
SUBSTITUTED IMIDAZOHETEROCYCLES
-
Page/Page column 68, (2009/01/24)
The present invention provides substituted imidazoheterocyclic compounds having the structure of formula I Also provided are pharmaceutically acceptable salts, acid salts, hydrates, solvates and stereoisomers of the compounds of formula I. The compounds are useful as modulators of cannabinoid receptors and for the prophylaxis and treatment of cannabinoid receptor-associated diseases and conditions, such as pain, inflammation and pruritis.