171356-57-3

Upstream product

• 148406-90-0 {(2R,3S)-3-[(R)-1-(Diphenyl-phosphinoyl)-2-methyl-propyl]-oxiranyl}-methanol 
• 145653-04-9 (E)-4-diphenylphosphinoyl-5-methylhex-2-en-1-ol 
• 100-46-9 benzylamine 
• 148314-40-3 (2S,3S)-3-[(R)-1-(Diphenyl-phosphinoyl)-2-methyl-propyl]-oxirane-2-carboxylic acid 

Relevant academic research and scientific papers

Control over absolute (R,S), relative (syn,anti) and geometrical (E,Z) stereochemistry in the synthesis of allylically substituted alkenes from diphenylphosphinoyl epoxy alcohols

Regioselective ring-openings of epoxy alcohols bearing a diphenylphosphinoyl (Ph2PO) group give diols which can undergo stereospecific Horner-Wittig elimination.This method was used to make allylic alcohols, unsaturated β-hydroxy sulfides, homoallylic alcohols and unsaturated amino acids, with control over their absolute (R,S), relative (syn,anti) and geometrical (E,Z) stereochemistry.

Stereocontrolled Synthesis of R or S, E or Z Unsaturated α-Amino Acids by Enantio- and Diastereoselective Epoxidation of δ-Hydroxy Allylic Phosphine Oxides

Epoxidation of δ-hydroxy allylic phosphine oxides 5 with m-CPBA can be syn selective.All stereoisomers of epoxy alcohols 6 are available when this method is used in tandem with an anti selective Sharpless kinetic resolution.The stereoisomers of epoxy alco