17142-76-6

Upstream product

• 137-07-5 2-amino-benzenethiol 
• 25026-34-0 4-chlorophenacetyl chloride 
• 873-73-4 4-n-chlorophenylacetylene 
• 1073-67-2 4-vinylbenzyl chloride 
• 27484-75-9 2,2'-trisulfanediyldianiline 
• 1141-88-4 2-Aminophenyl disulfide 
• 95-16-9 1,3-Benzothiazole 
• 106-43-4 para-chlorotoluene 
• 615-43-0 2-iodophenylamine 
• 99-91-2 para-chloroacetophenone 
• 75230-50-1 p-chloroacetophenone tosylhydrazone 
• 1615-02-7 p-chlorocinnamic acid 
• 93634-55-0 (Z)-4-(4-chlorobenzylidene)-2-methyloxazol-5(4H)-one 

Downstream Products

• 1060715-03-8 3-amino-2-(4-chlorobenzyl)-1,3-benzothiazol-3-ium 4-methylbenzenesulfonate 
• 33429-11-7 1,3-benzothiazol-2-yl(4-chlorophenyl)methanone 

Relevant academic research and scientific papers

S 8-Mediated Cyclization of Bis(2-aminophenyl) Disulfide/Diselenide with Arylacetylenes/Styrenes: Access to 2-(Arylmethyl)-1,3-benzothiazoles/benzoselenazoles

A novel S8-mediated approach to benzothiazoles/benzoselenazoles from bis(2-aminophenyl) disulfides/diselenides and phenylacetylenes or styrenes has been developed. 2-(Arylmethyl)-1,3-benzoselenazoles were comprehensively synthesized for the first time. The reactions proceeded in moderate to excellent yields, and with a gramscale application.

Elemental Sulfur-Promoted Benzoxazole/Benzothiazole Formation Using a C=C Double Bond as a One-Carbon Donator

An efficient method to assemble diverse benzoxazoles/benzothiazoles in good yields was developed via oxidative cyclization with 2-aminothiophenols or 2-iodoanilines as raw materials. In this protocol, elemental sulfur was used as the effective oxidant and C atoms on the C=C double bond were introduced as a one-carbon donator.

Photocatalytic synthesis method of C2 substituted 2H-benzothiazole benzylated derivative

The invention discloses a photocatalytic synthesis method of a C2 substituted 2H-benzothiazole benzylated derivative. The photocatalytic synthesis method comprises the following steps of: mixing 2H-benzothiazole with substituted methyl benzene; adding an oxidizing agent Selectfluor, an additive trifluoroacetic acid and a solvent acetonitrile, carrying out a normal temperature stirring reaction under the protection of nitrogen and the irradiation of an LED blue light lamp, carrying out TLC monitoring until the reaction is finished, and carrying out separation and purification on the reaction liquid to obtain the C2 substituted 2H-benzothiazole benzylated derivative. The new method for synthesizing the C2 substituted 2H-benzothiazole benzylated derivative through visible light induction by taking Selectfluor as an oxidizing agent, trifluoroacetic acid as an additive and acetonitrile as a solvent is high in atom economy, simple in catalytic system, good in product yield, wide in substraterange and suitable for popularization and application.

Method for synthesizing 2-substituted benzothiazole by one-pot method

The invention relates to a method for synthesizing 2-substituted benzothiazole by a one-pot method. The preparation method comprises the following specific steps: dissolving a 2-Iodoaniline compound,a styrene compound, elemental sulfur, an alkaline medium

Selective Construction of 2-Substituted Benzothiazoles from o-Iodoaniline Derivatives S8 and N-Tosylhydrazones

Selective construction of 2-substituted benzothiazoles from o-iodoaniline derivatives S8 and N-tosylhydrazone via a copper-promoted [3 + 1 + 1]-type cyclization reaction has been realized. In the protocol, the carbon atom on N-tosylhydrazone could be regulated to construct benzothiazole by changing the reaction system. Furthermore, the transformation has achieved the construction of multiple carbon-heteroatom bonds.

Elemental sulfur mediated 2-substituted benzothiazole formation from 2-aminobenzenethiols and arylacetylenes or styrenes under metal-free conditions

An oxidative cyclization of 2-aminothiophenols and arylacetylenes or styrenes for the synthesis of 2-alkylbenzothiazoles and 2-acylbenzothiazoles has been developed. Elemental sulfur was used as the effective oxidant to give the corresponding product in g

Elemental sulfur mediated synthesis of benzoxazoles, benzothiazoles and quinoxalines: Via decarboxylative coupling of 2-hydroxy/mercapto/amino-anilines with cinnamic acids

An easy and practical method has been developed for the synthesis of 2-benzylbenzoxazoles and 2-benzylbenzothiazoles using sulfur mediated decarboxylative coupling of cinnamic acids with 2-hydroxyanilines and 2-mercaptoanilines respectively under metal- and solvent-free conditions. However, the reaction of 2-aminoanilines with cinnamic acids leads to the formation of 2-arylquinoxalines under the same set of reaction conditions. The transformation is versatile and compatible with a number of functional groups.

Azlactones in heterocyclic synthesis: Part II - Condensation of 2-aminothiophenol with 2-oxazolin-5-ones

Condensation of 2-aminothiophenol (1) with 2-methyl-4-arylidene-2-oxazolin-5-ones (2,R=CH3) in acetic acid yields 2-aralkylbenzothiazoles (3) whereas with 2-phenyl-4-arylidene-2-oxazolin-5-ones (2,R=Ph) in dioxane it gives α-benzamido-2'-mercapto cinnaman