93634-55-0

Basic information

• Product Name: (Z)-4-(4-chlorobenzylidene)-2-methyloxazol-5(4H)-one
• Synonyms: (Z)-4-(4-chlorobenzylidene)-2-methyloxazol-5(4H)-one
• CAS NO: 93634-55-0
• Molecular Weight: 221.643
• Mol File: 93634-55-0.mol
• Article Data: 51

Chemical Properties

• CAS DataBase Reference: (Z)-4-(4-chlorobenzylidene)-2-methyloxazol-5(4H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: (Z)-4-(4-chlorobenzylidene)-2-methyloxazol-5(4H)-one(93634-55-0)
• EPA Substance Registry System: (Z)-4-(4-chlorobenzylidene)-2-methyloxazol-5(4H)-one(93634-55-0)

Safety Data

• Hazardous Substances Data: 93634-55-0(Hazardous Substances Data)

Usage

General Description

(Z)-4-(4-chlorobenzylidene)-2-methyloxazol-5(4H)-one is a chemical compound with a molecular formula C13H9ClNO2. It is a synthetic compound that belongs to the oxazole class of organic compounds and contains a chlorobenzylidene group. (Z)-4-(4-chlorobenzylidene)-2-methyloxazol-5(4H)-one is used in various research applications and has been studied for its potential pharmacological properties. It may have potential application in the development of pharmaceuticals or agrochemicals. Its chemical structure and properties make it suitable for further exploration in the fields of medicinal chemistry and drug discovery.

Upstream product

• 104-88-1 4-chlorobenzaldehyde 
• 64-19-7 acetic acid 
• 56-40-6 glycine 
• 1906-82-7 ethyl acetamidoacetate 
• 24474-93-9 2-methyl-4H-oxazol-5-one 
• 543-24-8 N-acetylglycine 
• 5356-71-8 1,3-diphenyl-1H-pyrazol-5-amine 

Downstream Products

• 74168-95-9 5-(4-chloro-benzylidene)-2-methyl-3-thiazol-2-yl-3,5-dihydro-imidazol-4-one 
• 127273-12-5 3-(4-chlorophenyl)-2-hydroxyacrylic acid 
• 181423-29-0 (Z)-2-acetylamino-N-butyl-3-(4-chlorophenyl)-2-propenamide 
• 102245-02-3 methyl (Z)-2-acetylamino-3-(4-chlorophenyl)-2-propenoate 
• 66373-63-5 6-methylbenzimidazo<1,2-c>quinazoline 
• 3617-01-4 β-(4-chlorophenyl)pyruvic acid 
• 1273258-47-1 1,4:3,6-dianhydro-2,5-bis-[2-acetamido-(Z)-4-chlorocinnamamido]-2,5-dideoxy-L-iditol 
• 52217-00-2 (Z)-3-(4-chlorophenyl)-2-methoxyacrylic acid 
• 1357447-86-9 (Z)-3-(4-chlorophenyl)-2-methoxy-N-phenylacrylamide 
• 1357447-87-0 (Z)-3-(4-chlorophenyl)-N-(4-fluorophenyl)-2-methoxyacrylamide 
• 1357447-88-1 (Z)-N,3-bis(4-chlorophenyl)-2-methoxyacrylamide 
• 27034-51-1 ethyl 6-chloro-1H-indole-2-carboxylate 
• 33401-57-9 6-(4-chlorobenzyl)-3-thioxo-3,4-dihydro-[1,2,4]-triazin-5(2H)-one 

Relevant articles and documents

Mechanistically Guided One Pot Synthesis of Phosphine-Phosphite and Its Implication in Asymmetric Hydrogenation

Although hybrid bidentate ligands are known to yield highly enantioselective products in asymmetric hydrogenation (AH), synthesis of these ligands is an arduous process. Herein, a one pot, atom-economic synthesis of a hybrid phosphine-phosphite (L1) is reported. After understanding the reactivity difference between an O-nucleophile versus C-nucleophile, one pot synthesis of Senphos (L1) was achieved (72 %). When L1 was treated with [Rh], 31P NMR revealed bidentate coordination to Rh. Senphos, in the presence of rhodium, catalyzes the AH of Methyl-2-acetamido-3-phenylacrylate and discloses an unprecedented turn over frequency of 2289, along with excellent enantio-selectivity (92 %). The generality is demonstrated by hydrogenating an array of alkenes. The AH operates under mild conditions of 1–2 bar H2 pressure, at room temperature. The practical relevance of L1 is demonstrated by scaling-up the reaction to 1 g and by synthesizing DOPA, a drug widely employed for the treatment of Parkinson's disease. Computational insights indicate that the R isomer is preferred by 3.8 kcal/mol over the S isomer.

Concise synthesis and applications of enantiopure spirobiphenoxasilin-diol and its related chiral ligands

The development of chiral architectures for chiral ligand and catalyst discovery is essential for asymmetric catalysis. Herein, we report the concise synthesis of a Si-centered spirocyclic skeleton, spirobiphenoxasilin-diol (SPOSiOL), and its derived chiral ligands. Using the chemical resolution method, the optical SPOSiOL could be obtained in high yield on a gram scale. Preliminary studies indicated that this ligand scaffold has great potential in transition metal-catalyzed asymmetric reactions. This finding further highlights that the Si-centered spirocyclic scaffolds are of great value in asymmetric catalysis. This journal is

Synthesis and preliminary biological evaluation of antibacterial and antifungal 5-arylidene tetramic acid-cadmium(II) complexes

The synthesis and biological evaluation of 5-arylidene-N-acetyl-tetramic acids cadmium(II) complexes are reported. Eleven novel compounds were prepared, characterized by nuclear magnetic resonance experiments and screened for their antimicrobial activity