171485-39-5

Basic information

• Product Name: (aR)-alpha-[(1S)-1-[2,6-Dimethoxy-4-(2-propen-1-yl)phenoxy]ethyl]-4-hydroxy-3-methoxybenzenemethanol
• Synonyms: (aR)-alpha-[(1S)-1-[2,6-Dimethoxy-4-(2-propen-1-yl)phenoxy]ethyl]-4-hydroxy-3-methoxybenzenemethanol;Myrislignan;(-)-erythro-(7R,8S)-8'-4,7-dihydroxy-3,3',5'-triMethoxy-8-O-4'-neolignan
• CAS NO: 171485-39-5
• Molecular Formula: C21H26O6
• Molecular Weight: 374.43
• Product Categories: chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract
• Mol File: 171485-39-5.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 537.6±50.0 °C(Predicted)
• Appearance: /
• Density: 1.167
• PKA: 9.94±0.31(Predicted)
• CAS DataBase Reference: (aR)-alpha-[(1S)-1-[2,6-Dimethoxy-4-(2-propen-1-yl)phenoxy]ethyl]-4-hydroxy-3-methoxybenzenemethanol(CAS DataBase Reference)
• NIST Chemistry Reference: (aR)-alpha-[(1S)-1-[2,6-Dimethoxy-4-(2-propen-1-yl)phenoxy]ethyl]-4-hydroxy-3-methoxybenzenemethanol(171485-39-5)
• EPA Substance Registry System: (aR)-alpha-[(1S)-1-[2,6-Dimethoxy-4-(2-propen-1-yl)phenoxy]ethyl]-4-hydroxy-3-methoxybenzenemethanol(171485-39-5)

Safety Data

• Hazardous Substances Data: 171485-39-5(Hazardous Substances Data)

Usage

General Description

(aR)-alpha-[(1S)-1-[2,6-Dimethoxy-4-(2-propen-1-yl)phenoxy]ethyl]-4-hydroxy-3-methoxybenzenemethanol, also known as artemetin, is a natural chemical compound derived from the plant Artemisia annua, commonly known as sweet wormwood. It is known for its anti-malarial properties and has been used for centuries in traditional Chinese medicine to treat fevers. Artemetin has also been studied for its potential anti-cancer properties, as it has shown the ability to inhibit the growth of various types of cancer cells. Additionally, it has demonstrated anti-inflammatory and antioxidant effects, making it a promising compound for potential therapeutic applications.

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Relevant articles and documents

Identification of a Novel TRPM8 Agonist from Nutmeg: A Promising Cooling Compound

The transient receptor potential melastatin 8 (TRPM8) ion channel is the primary receptor for innocuous cold stimuli (8′-7-ethoxy-4-hydroxy-3,3′,5′-trimethoxy-8-O-4′-neolignan (1) with an EC50 of 0.332 μM, which was isolated from a well-known spice, nutmeg (Myristica fragrans Houtt.). Structure activity relationships are also disclosed, showing that the 7-d-menthoxy derivative is the most potent agonist (EC50 = 11 nM). The combination of 1 and l-(-)-menthol has an additive effect, suggesting that neolignan compounds interact with TRPM8 at different sites from those of l-(-)-menthol.