171486-04-7Relevant articles and documents
PEPTIDE NUCLEIC ACID MONOMERS AND OLIGOMERS
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, (2011/10/13)
Disclosed is a peptide nucleic acid monomer as well as a corresponding peptide nucleic acid molecule. The monomer comprises a terminal amino group and a terminal group A. The terminal amino group and the terminal group A are connected by an aliphatic moie
Acyclic nucleotide analogues on the basis of phosphonic acids
Efimtseva,Mikhailov,Fomicheva,Meshkov,Rodionov,Khomutov,De Clercq
, p. 12 - 16 (2007/10/03)
The synthesis of novel nucleotide analogues on the basis of ethylphosphonic acids was described. A rigid structural element, an amide, or a double bond, was characteristic of the compounds synthesized. The antiviral and cytotoxic activities of these compo
Oligonucleotide analogues with 4-hydroxy-N-acetylprolinol as sugar substitute
Ceulemans, Griet,Van Aerschot, Arthur,Wroblowski, Berthold,Rozenski, Jef,Hendrix, Chris,Herdewijn, Piet
, p. 1997 - 2010 (2007/10/03)
Modified oligonucleotides incorporating trans-4-hydroxy-N-acetyl-L-prolinol (trans-4-HO-L-NAP) or its D-analogue as sugar substitute were synthesised with adenine and thymine as nucleobases. All-adenine oligonucleotides built from (2S,4S) or (2R,4R)-cis-4
Nucleosides and Oligonucleotides Derived from trans-4-Hydroxy-N-acetylprolinol
Ceulemans, G.,Aerschot, A. Van,Herdewijn, P.
, p. S234 - S237 (2007/10/03)
The 4-O-phosphoramidites of monomethoxytritylated 4-hydroxy-N-6-benzoyladenin-9-yl)acetyl>prolinol and 4-hydroxy-N-prolinol were prepared for incorporation into nucleic acids.The L-trans all-adenine oligonucleotide (ON) hybridises to natural oligothymidylate, apparently via triplex formation.All-purine sequences of the L-trans form can also form homo-complexes with their pyrimidine counterpart.The D-trans compounds give larger destabilisation when inserted in DNA.D-trans all-adenine ONs do not form complexes with natural oligothymidylate.For this series of modified ONs no hybridisation could be detected between complementary strands of opposite enantiomeric form.
Synthesis and Biochemical Properties of Phosphonyl Acyclic Analogs of 2'Deoxyadenosine Nucleotides
Malakhov, D. V.,Semizarov, D. G.,Yas'ko, M. V.
, p. 464 - 469 (2007/10/03)
9-adenine, 9-adenine, 9-ethyl>adenine, and their diphosphates were synthesized.All three diphosphates were shown to incorporate into the 3'-te
Acyclic nucleoside and nucleotide analogues with amide bond
Efimtseva,Mikhailov,Jasko,Malakhov,Semizarov,Fomicheva,Kern
, p. 373 - 375 (2007/10/02)
A series of acyclic nucleosides and related α-phosphonyl acyclic analogues of dNTP with an amide bond have been prepared. Their antiviral and substrate properties were investigated.
