171503-94-9Relevant academic research and scientific papers
Synthesis of functionalised 2'-C-branched nucleosides via their γ-butyrolactones
Lawrence,Pavey,O'Neil,Cosstick
, p. 6341 - 6344 (1995)
Functionalised 2'-C-branched nucleosides that contain either a carboxylic acid (2), a primary amide (3) or a primary hydroxyl (4) group have been prepared and their protection for oligonucleotide synthesis investigated. The 2'-C-3'-O-γ-butyrolactone (5) w
Synthesis, structure and reactions of uridine 2′-C,3′-O-γ-butyro-lactone: Versatile intermediate for the synthesis of 2′-C-branched nucleosides
Lawrence, Anthony J.,Pavey, John B. J.,Chan, Mai-Yee,Fairhurst, Robin A.,Collingwood, Stephen P.,Fisher, Julie,Cosstick, Richard,O'Neil, Ian A.
, p. 2761 - 2767 (2007/10/03)
Uridine 2′-C-3′-O-γ-butyrolactone 5a has been prepared by cyclisation of 2′-α-C-carboxymethyl-2′-deoxyuridine 8 in acetic acid-methanol. Detailed 1H NMR studies on compound 5a clearly demonstrate cis fusion between the γ-lactone and the sugar m
