171515-04-1

Basic information

• Product Name: 2-Carboxy-3-amino-4-trifluoromethyl-6-phenylfuro<2,3-b>pyridine
• Synonyms: 2-Carboxy-3-amino-4-trifluoromethyl-6-phenylfuro<2,3-b>pyridine
• CAS NO: 171515-04-1
• Molecular Weight: 322.243
• Mol File: 171515-04-1.mol

Chemical Properties

• CAS DataBase Reference: 2-Carboxy-3-amino-4-trifluoromethyl-6-phenylfuro<2,3-b>pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Carboxy-3-amino-4-trifluoromethyl-6-phenylfuro<2,3-b>pyridine(171515-04-1)
• EPA Substance Registry System: 2-Carboxy-3-amino-4-trifluoromethyl-6-phenylfuro<2,3-b>pyridine(171515-04-1)

Safety Data

• Hazardous Substances Data: 171515-04-1(Hazardous Substances Data)

Upstream product

• 326-06-7 1-Phenyl-4,4,4-trifluorobutane-1,3-dione 
• 98-86-2 acetophenone 
• 3335-44-2 2-oxo-6-phenyl-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile 
• 160436-48-6 2-carbethoxy-3-amino-4-trifluoromethyl-6-phenylfuro-<2,3-b>-pyridine 

Downstream Products

• 171515-11-0 2-Carboxy-3-trifluoroacetylamino-4-trifluoromethyl-6-phenylfuro<2,3-b>pyridine 
• 171515-17-6 2,9-Bis(trifluoromethyl)-7-phenyl-4-oxo-4H-pyrido<3',2':4,5>furo<3,2-d>-1,3-oxazine 
• 160436-52-2 2-carbohydrazide-3-amino-4-trifluoromethyl-6-phenylfuro-<2,3-b>-pyridine 
• 546834-60-0 4-trifluoromethyl-6-phenylfuro[2,3-b]pyridine-3(2H)-one 
• 171515-14-3 2-Methyl-7-phenyl-9-trifluoromethyl-4-oxo-4H-pyrido<3',2':4,5>furo<3,2-d>-1,3-oxazine 

Relevant articles and documents

Discovery and structure-activity relationships study of novel thieno[2,3-b]pyridine analogues as hepatitis C virus inhibitors

Current treatment for hepatitis C is barely satisfactory, there is an urgent need to develop novel agents for combating hepatitis C virus infection. This study discovered a new class of thieno[2,3-b]pyridine derivatives as HCV inhibitors. First, a hit compound characterized by a thienopyridine core was identified in a cell-based screening of our privileged small molecule library. And then, structure activity relationship study of the hit compound led to the discovery of several potent compounds without obvious cytotoxicity in vitro (12c, EC50 = 3.3 μM, SI >30.3, 12b, EC50 = 3.5 μM, SI >28.6, 10l, EC50 = 3.9 μM, SI >25.6, 12o, EC 50 = 4.5 μM, SI >22.2, respectively). Although the mechanism of them had not been clearly elucidated, our preliminary optimization of this class of compounds had provided us a start point to develop new anti-HCV agents.

A facile synthesis of 4-oxo-1,2,3,4-tetrahydropyrido [3′,2′:4,5] furo-[3,2-d]pyridines: A new tricyclic heterocyclic ring system

2-Acetyl-3-amino-4-trifluoromethyl-6-substitutedphenylfuro[2,3-b]pyridines are subjected to Claisen-Schmidth condensation with different arylaldehydes followed by intramolecular Michael type addition to obtain 4-oxo-1,2,3,4-tetrahydropyrido [3′,2′:4,5]fur

Fluoro organics: synthesis of novel fluorinated 4-oxo-4H-pyridofuro-1,3-oxazines and their reactions

Novel fluorinated 4-oxo-4H-pyridofuro-1,3-oxazines have been synthesised from 2-carbethoxy-3-amino-4-trifluoromethyl-6-aryl-substituted furopyridines via intermediates such as 2-carboxy-3-amino-4-trifluoromethyl-6-aryl-substituted