171561-72-1

Upstream product

• 14231-57-3 (R)-N-benzyl-2-phenylglycinol 
• 122-78-1 phenylacetaldehyde 
• 98-88-4 benzoyl chloride 
• 74213-58-4 N-[(1R)-2-hydroxy-1-phenylethyl]benzamide 
• 56613-80-0 D-2-phenylglycinol 

Relevant academic research and scientific papers

Asymmetric synthesis of α-amino phosphonic acids by diastereoselective addition of trimethyl phosphite onto chiral oxazolidines

A simple and general asymmetric synthesis of α-amino phosphonic acids is described. The method involves the highly selective addition of trialkyl phosphite onto various chiral oxazolidines. Oxazaphosphorinanes thus obtained with an excellent diastereoselectivity furnish the corresponding (S)-α-substituted amino phosphonic acids in good overall yields and high ee (77→97%) after simple deprotection.

STEREOSELECTIVE SYNTHESIS OF OPTICALLY ACTIVE DIETHANOLOAMINES UTILIZING DIASTEREOSELECTIVE REACTION OF 1,3-OXAZOLIDINES WITH GRIGNARD REAGENTS

The highly diastereoselective addition of isopropoxydimethylsilylmethylmagnesium chloride to N-benzyl-1,3-oxazolidines derived from (R)-phenylglycinol, followed by oxidation of adducts with hydrogen peroxide in the presence of potassium fluoride, provided the 1-substituted (1R, 1'R)-N-benzyl-1'-phenyl-2,2'-dihydroxydiethylamines (1a-d).