17159-86-3

Upstream product

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• 23521-81-5 (1,4-dioxaspiro[4.5]dec-8-yl)methanol 
• 75-03-6 ethyl iodide 
• 26934-56-5 1,4-dioxaspiro[4.5]decan-8-ylmethyl 4-methylbenzenesulfonate 
• 64-17-5 ethanol 
• 17159-83-0 4-<<(p-tolylsulfonyl)oxy>methyl>cyclohexanone 

Relevant academic research and scientific papers

CYCLOHEXYL-AZETIDINYL ANTAGONISTS OF CCR2

The present invention comprises compounds of Formula (I). wherein: R1, R2, X, and Z are as defined in the specification. The invention also comprises a method of preventing, treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is type II diabetes, obesity and asthma. The invention also comprises a method of inhibiting CCR2 activity in a mammal by administration of a therapeutically effective amount of at least one compound of Formula (I).

NOVEL COMPOUNDS-300

Compounds of Formula I, or pharmaceutically acceptable salts thereof: wherein R1, R2, R3, R4, m, n, q, s, t, X, and Y are as defined in the specification as well as salts and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.