171614-03-2

Upstream product

• 69739-34-0 t-butyldimethylsiyl triflate 
• 171614-02-1 5'-O-(dimethoxytrityl)-2-azainosine 
• 2627-69-2 AICA riboside 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 36519-16-1 7-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3,7-dihydro-4H-imidazo[4,5-d][1,2,3]triazin-4-one 
• 18162-48-6 tert-butyldimethylsilyl chloride 

Downstream Products

• 171614-04-3 3'-O-(tert-butyldimethylsilyl)-5'-O-(dimethoxytrityl)-2'-(phenoxythiocarbonyl)-2-azainosine 
• 1053692-67-3 7-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-3-(2-nitro-benzyl)-3,7-dihydro-imidazo[4,5-d][1,2,3]triazin-4-one 
• 171614-01-0 5'-O-(dimethoxytrityl)-N¹-(2-nitrobenzyl)-2-aza-2'-deoxyinosine 
• 171614-05-4 3'-O-(tert-butyldimethylsilyl)-5'-O(dimethoxytrityl)-2-aza-2'-deoxyinosine 

Relevant academic research and scientific papers

CYCLIC DINUCLEOTIDE COMPOUNDS CONTAINING 2-AZA-HYPOXANTHINE OR 6H-PYTAZOLO[1,5-D][1,2,4]TRIAZIN-7-ONE AS STING AGONISTS

Compounds of formula I, wherein Base, R1 and R2 are defined as in claim 1, are modulators of STING.

Synthesis and biophysical and biological properties of oligonucleotides containing 2-aza-2'-deoxyinosine

The preparation of oligonucleotides containing 2-aza-2'-deoxyinosine is described. Protection of the 2-azahypoxanthine moiety with the photolabile 2-nitrobenzyl group enabled us to obtain the phosphoramidite derivative and oligonucleotides containing protected 2-aza-2'-deoxyinosine. After purification, photolysis of the oligonucleotides containing the protected analogue provided the desired oligonucleotides in good yields. Melting curves of duplexes containing 2-azahypoxanthine paired with the four natural bases at pH 6 and pH 8 proved that 2-azahypoxanthine base pairs were less stable than perfectly matched duplexes but showed little variation among different bases.