171672-71-2

Upstream product

• 27784-76-5 tert-butyl diethylphosphonoacetate 
• 58107-34-9 (E)-3-trimethylsilyl-2-propenal 
• 171672-70-1 (2E,4E)-5-Trimethylsilanyl-penta-2,4-dienoic acid tert-butyl ester 

Downstream Products

• 171672-73-4 (E)-(S)-3-((R)-1-Phenyl-ethylamino)-5-trimethylsilanyl-pent-4-enoic acid 
• 171672-74-5 (S)-1-((R)-1-Phenyl-ethyl)-4-((E)-2-trimethylsilanyl-vinyl)-azetidin-2-one 
• 171672-77-8 (S)-4-((E)-2-Methoxy-vinyl)-1-((R)-1-phenyl-ethyl)-azetidin-2-one 
• 171672-72-3 (E)-(S)-3-((R)-1-Phenyl-ethylamino)-5-trimethylsilanyl-pent-4-enoic acid tert-butyl ester 

Relevant academic research and scientific papers

A Formal Total Asymmetric Synthesis of (+)-Thienamycin

Synthesis of an enantiomerically pure intermediate to (+)-thienamycin is presented: the pivotal reaction in this sequence is the highly diastereoselective Michael addition of a differentially protected lithium amide.