A Formal Total Asymmetric Synthesis of (+)-Thienamycin

DOI: 10.1016/0957-4166(95)00327-L

Source and publish data:

Tetrahedron Asymmetry p. 2507 - 2510 (1995)

Update date:2022-08-04

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Authors:

Davies, Stephen G.

Hedgecock, Charles J. R.

McKenna, Jeffrey M.

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Article abstract of DOI:10.1016/0957-4166(95)00327-L

Synthesis of an enantiomerically pure intermediate to (+)-thienamycin is presented: the pivotal reaction in this sequence is the highly diastereoselective Michael addition of a differentially protected lithium amide.

Full text of DOI:10.1016/0957-4166(95)00327-L

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Product name:(E)-(S)-3-[Allyl-((R)-1-phenyl-ethyl)-amino]-5-trimethylsilanyl-pent-4-enoic acid tert-butyl ester

Cas No:171672-71-2

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