171815-01-3

Basic information

• Product Name: N-[9-((2R,3S,3aR,9aR)-3-Bromo-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-9H-purin-6-yl]-benzamide
• CAS NO: 171815-01-3
• Molecular Weight: 676.758
• Mol File: 171815-01-3.mol

Chemical Properties

• CAS DataBase Reference: N-[9-((2R,3S,3aR,9aR)-3-Bromo-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-9H-purin-6-yl]-benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[9-((2R,3S,3aR,9aR)-3-Bromo-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-9H-purin-6-yl]-benzamide(171815-01-3)
• EPA Substance Registry System: N-[9-((2R,3S,3aR,9aR)-3-Bromo-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-9H-purin-6-yl]-benzamide(171815-01-3)

Safety Data

• Hazardous Substances Data: 171815-01-3(Hazardous Substances Data)

Upstream product

• 88121-20-4 3′,5′-O-(1,1,3,3-tetraisopropyldisiloxyl)-2′-O-(trifluormethylsulfonyl)adenosine 
• 98-88-4 benzoyl chloride 
• 88121-22-6 9-((2R,3S,3aR,9aR)-3-Bromo-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-9H-purin-6-ylamine 

Downstream Products

• 181714-64-7 N-(9-{(2R,3S,4R,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-bromo-4-hydroxy-tetrahydro-furan-2-yl}-9H-purin-6-yl)-benzamide 
• 181714-63-6 N-[9-((2R,3S,4R,5R)-3-Bromo-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-9H-purin-6-yl]-benzamide 

Relevant articles and documents

Nucleosides and nucleotides. 153. Effects of 2'α- and 2'-β-bromo-2'- deoxyadenosine on oligonucleotide hybridization and nuclease stability

1-(2-Bromo-2-deoxy-β-D-ribofuranosyl)adenine (1) and 1-(2-bromo-2- deoxy-β-D-arabinofuranosyl)adenine (2) were incorporated into DNA pentadecamers. The oligonucleotides containing 1 destabilized DNA/DNA and DNA/RNA duplex formation. However, the oligonucleotides containing 2 slightly stabilized DNA/DNA duplex formation, although they decreased the stability of DNA/RNA duplexes. Furthermore, the oligonucleotide containing 2 was more resistant to snake venom phosphodiesterase than an unmodified oligonucleotide (dA)15 and the oligonucleotide containing 1.