171820-09-0

Basic information

• Product Name: Phenol, 4,4'-(2,6-pyrazinediyl)bis-
• CAS NO: 171820-09-0
• Molecular Formula: C16H12N2O2
• Molecular Weight: 264.283
• Mol File: 171820-09-0.mol

Chemical Properties

• CAS DataBase Reference: Phenol, 4,4'-(2,6-pyrazinediyl)bis-(CAS DataBase Reference)
• NIST Chemistry Reference: Phenol, 4,4'-(2,6-pyrazinediyl)bis-(171820-09-0)
• EPA Substance Registry System: Phenol, 4,4'-(2,6-pyrazinediyl)bis-(171820-09-0)

Safety Data

• Hazardous Substances Data: 171820-09-0(Hazardous Substances Data)

Upstream product

• 135459-44-8 2,6-bis-(4-methoxy-phenyl)-pyrazine 
• 5720-07-0 4-methoxyphenylboronic acid 
• 2491-38-5 2-bromo-1-(4'-hydroxyphenyl)-1-ethanone 

Downstream Products

• 1027181-17-4 2,6-bis-(4-cyanomethoxy-phenyl)-pyrazine 

Relevant articles and documents

Selective synthesis of oxazoles and pyrazines from α-bromo-1-phenylethanone using a by-product-promoted strategy

Oxazoles and pyrazines are fundamental heterocycles that widely found in natural products or drugs. In this work, a selective strategy for oxazoles and pyrazines synthesis using α-bromo-1-phenylethanone and ammonium acetate as starting materials was reported. This methodology features mild reaction conditions, readily accessible starting materials and good chemoselectivity. Mechanistic study indicates that this reaction involves a by-product-promoted (BPP) process for the formation of oxazole, that is, the in-situ formed hydrogen bromide (HBr) during the reaction promotes the whole tandem process.

Synthesis of 2,6-diphenylpyrazine derivatives and their DNA binding and cytotoxic properties

A series of 2,6-diphenylpyrazine derivatives was synthesized from 2,6-dichloropyrazine and 4-methoxyphenylboronic acid using palladium(0) as catalyst in a Suzuki methodology. After deprotection of the hydroxyl, alkylation reactions with different halides