171827-01-3

Upstream product

• 34097-60-4 methyl benzenesulfonylacetate 
• 171826-98-5 (E)-methyl 3-(4-bromo-3-methyl-2-butenyl)-4-methoxy-2-((2-methoxyethoxy)methoxy)-5-methylbenzoate 
• 171826-92-9 (E)-2-methyl-4-<2-((methoxyethoxy)methoxy)-1-(methoxycarbonyl)-4-methoxy-5-methyl-3-phenyl>-2-butenal 
• 171826-95-2 (E)-methyl 3-(3-methyl-4-hydroxy-2-butenyl)-4-methoxy-2-((2-methoxyethoxy)methoxy)-5-methylbenzoate 
• 171826-89-4 (E)-2-methyl-4-(2-hydroxy-1-(methoxycarbonyl)-4-methoxy-5-methyl-3-phenyl)-2-butenal 
• 171826-86-1 2-(2-hydroxy-4-methoxy-5-methyl-1-(methoxycarbonyl)-3-phenyl)ethanal 
• 171826-83-8 methyl 3-allyl-2-hydroxy-4-methoxy-5-methylbenzoate 
• 171826-81-6 methyl 2-(allyloxy)-4-methoxy-5-methylbenzoate 
• 39503-63-4 methyl 5-formyl-2,4-dimethoxybenzoate 
• 93351-75-8 methyl 2,4-dimethoxy-5-methylbenzoate 
• 39503-29-2 methyl 2-hydroxy-4-methoxy-5-methylbenzoate 

Downstream Products

• 171827-07-9 2-Hydroxy-4-methoxy-3-((E)-5-methoxycarbonyl-3-methyl-pent-2-enyl)-5-methyl-benzoic acid methyl ester 
• 171826-74-7 3-((E)-5-Carboxy-3-methyl-pent-2-enyl)-2-hydroxy-4-methoxy-5-methyl-benzoic acid methyl ester 
• 171827-04-6 (E)-methyl 4-methyl-6-<3-<1-(methoxycarbonyl)-2-((2-methoxyethoxy)methoxy)-4-methoxy-5-methylphenyl>>-4-hexenoate 

Relevant academic research and scientific papers

Synthesis and modeling studies with monocyclic analogues of mycophenolic acid

Two stepwise procedures, developed for the introduction of the (E)-4- methyl-4-hexenoic acid side chain of mycophenolic acid, were used in the synthesis of monocyclic mycophenolic acid analogues 2a-i. The derivatives with a methyl group or hydrogen at C-4 and lacking the lactone moiety were much less cytotoxic than mycophenolic acid. The menocyclic analogues with a C-4 chloro group did show some activity, albeit much less than mycophenolic acid. The observed differences in potency are rationalized by semiempirical calculations of intramolecular H-bonds.