171869-48-0

Upstream product

• 124-63-0 methanesulfonyl chloride 
• 172586-62-8 2'-O-acetyl-7α-paclitaxel 

Downstream Products

• 171780-95-3 2'-O-acetyl-Δ^6,7-paclitaxel 
• 158830-49-0 Δ^6,7-paclitaxel 
• 171780-96-4 4-deacetoxy-4α-hydroxy-4β-hydroxymethyl-5α-acetoxy-Δ^6,7-20-O-seco-paclitaxel 

Relevant academic research and scientific papers

Synthesis of 7beta-sulfur analogues of paclitaxel utilizing a novel epimerization of the 7alpha-thiol group.

Paclitaxel analogues with a sulfur group at the 7beta position were required for SAR studies. Attempts to generate these compounds by displacing a 7alpha leaving group with sulfur nucleophiles were unsuccessful. Instead, these compounds were successfully

Synthesis and Molecular Modeling of Taxanes Modified at Ring C

Some new paclitaxel analogs, modified at ring C, - namely the 7-α-mesylate, 7-deoxy-7-α-amino, 4-deacetoxy-4α-hydroxy-4β-hydroxymethyl-5α-acetoxy-Δ6,7-20-O-seco and 4-deacetoxy-4α-hydroxy-4β-hydroxymethyl-5α-acetoxy-6,7-epoxy-20-O-seco derivatives - are presented. The biological activity of 4-deacetoxy-4α-hydroxy-4β-hydroxymethyl-5α-acetoxy-Δ6,7-20-O-seco, 4-deacetoxy-4α-hydroxy-4β-hydroxymethyl-5α-acetoxy-6,7-epoxy-20-O-seco, 7-deoxy-7-α-azido, 7-deoxy-7-α-amino and 6,7-epoxy derivatives heve been evaluated. A molecular modeling study on some paclitaxel derivatives has been done in an attempt to rationalize the difference in biological activity.