171872-13-2Relevant academic research and scientific papers
Orally active trifluoromethyl ketone inhibitors of human leukocyte elastase
Veale, Chris A.,Bernstein, Peter R.,Bohnert, Claudia M.,Brown, Frederick J.,Bryant, Craig,Damewood Jr., James R.,Earley, Roger,Feeney, Scott W.,Edwards, Philip D.,Gomes, Bruce,Hulsizer, James M.,Kosmider, Ben J.,Krell, Robert D.,Moore, Gary,Salcedo, Theodora W.,Shaw, Andrew,Silberstein, David S.,Steelman, Gary B.,Stein, Mark,Strimpler, Anne,Thomas, Roy M.,Vacek, Edward P.,Williams, Joseph C.,Wolanin, Donald J.,Woolson, Sheila
, p. 3173 - 3181 (2007/10/03)
This paper describes the development a series of peptidyl trifluoromethyl ketone inhibitors of human leukocyte elastase which are found to have excellent pharmacological profiles. Methods have been developed that allow for the synthesis of these inhibitor
