171964-73-1Relevant academic research and scientific papers
Orally active trifluoromethyl ketone inhibitors of human leukocyte elastase
Veale, Chris A.,Bernstein, Peter R.,Bohnert, Claudia M.,Brown, Frederick J.,Bryant, Craig,Damewood Jr., James R.,Earley, Roger,Feeney, Scott W.,Edwards, Philip D.,Gomes, Bruce,Hulsizer, James M.,Kosmider, Ben J.,Krell, Robert D.,Moore, Gary,Salcedo, Theodora W.,Shaw, Andrew,Silberstein, David S.,Steelman, Gary B.,Stein, Mark,Strimpler, Anne,Thomas, Roy M.,Vacek, Edward P.,Williams, Joseph C.,Wolanin, Donald J.,Woolson, Sheila
, p. 3173 - 3181 (2007/10/03)
This paper describes the development a series of peptidyl trifluoromethyl ketone inhibitors of human leukocyte elastase which are found to have excellent pharmacological profiles. Methods have been developed that allow for the synthesis of these inhibitor
Discovery and biological activity of orally active peptidyl trifluoromethyl ketone inhibitors of human neutrophil elastase
Edwards, Philip D.,Andisik, Donald W.,Bryant, Craig A.,Ewing, Barbara,Gomes, Bruce,Lewis, Joseph J.,Rakiewicz, Donna,Steelman, Gary,Strimpler, Ann,Trainor, Diane A.,Tuthill, Paul A.,Mauger, Russell C.,Veale, Chris A.,Wildonger, Richard A.,Williams, Joseph C.,Wolanin, Donald J.,Zottola, Mark
, p. 1876 - 1885 (2007/10/03)
Previously we had shown that tripeptidyl trifluoromethyl ketones (TFMKs) possessing an N-terminal diarylacylsulfonamide, such as ICI 200,880 and ICI 200,355, displayed unparalleled protection against the lung damage induced by human neutrophil elastase (H
