171919-37-2

Basic information

• Product Name: 1-Methyl-7-azaindole-3-carboxylic acid
• Synonyms: 1-Methyl-7-azaindole-3-carboxylic acid;1-Methyl-7-azaindole-3-ca...;1H-Pyrrolo[2,3-b]pyridine-3-carboxylic acid, 1-Methyl-;1-methyl-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid
• CAS NO: 171919-37-2
• Molecular Formula: C₉H₈N₂O₂
• Molecular Weight: 176.17202
• Mol File: 171919-37-2.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-Methyl-7-azaindole-3-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Methyl-7-azaindole-3-carboxylic acid(171919-37-2)
• EPA Substance Registry System: 1-Methyl-7-azaindole-3-carboxylic acid(171919-37-2)

Safety Data

• Hazardous Substances Data: 171919-37-2(Hazardous Substances Data)

Usage

General Description

1-Methyl-7-azaindole-3-carboxylic acid is a chemical compound with the molecular formula C10H8N2O2. It is a derivative of indole, containing a carboxylic acid group and a methyl group at the 1 and 7 positions, respectively. 1-Methyl-7-azaindole-3-carboxylic acid is commonly used as a building block in the synthesis of pharmaceuticals and agrochemicals, due to its versatile reactivity and potential for introducing specific functional groups. It is also known for its potential biological activity, making it a valuable intermediate in the development of new drugs. Overall, 1-Methyl-7-azaindole-3-carboxylic acid is a significant chemical in the fields of medicinal and organic chemistry.

Upstream product

• 271-63-6 7-Azaindole 
• 4414-89-5 1H-pyrrolo[2,3-b]pyridine-3-carbonitrile 
• 27257-15-4 1-methyl-1H-pyrrolo[2,3-b]pyridine 
• 171919-36-1 1-methyl-1H-pyrrolo<2,3-b>pyridine-3-carbaldehyde 

Downstream Products

• 1312556-91-4 (S)-N,1-dimethyl-N-(4-(1-methyl-1H-pyrrole-2-carboxamido)phenylbutan-2-yl)-1H-pyrrolo[2,3-b]pyridine-3-carboxamide 

Relevant articles and documents

TOPICAL FORMULATIONS

Provided herein are gelled topical formulations for the treatment of skin diseases comprising: a) a MEK inhibitor; b) one or more organic solvents in an amount of about 70% to about 99% by weight; and c) a gelling agent; wherein the one or more organic solvents are selected from the group consisting of C2-6 alcohol, a C2-6 alkylene glycol, a di-(C2-6 alkylene) glycol, a polyethylene glycol, C1-3 alkyl-(OCH2CH2)1-5-OH, DMSO, ethyl acetate, acetone, N-methyl pyrrolidone, benzyl alcohol, glycerin, and an oil; the gelling agent is hydroxypropyl cellulose having a molecular weight ranging from about 40,000 Dato about 2,500,000 Da; and wherein the gelled topical formulation has a viscosity of from 1 to 25,000 cps; and DMSO, when present, is combined with at least one other of said organic solvents such that DMSO is present in an amount of less than 50% by weight.

ARYL-ANILINE AND HETEROARYL-ANILINE COMPOUNDS FOR TREATMENT OF SKIN CANCERS

Provided herein are compounds and pharmaceutical compositions thereof for treating a skin cancer in a subject in need thereof, wherein the compound is according to any one of formula (I), (II), (III), (IV), and (V): wherein X1, X2, X3, R1, R2, R2a, R13, Rl3a, R23, R23a, R23b, R33, R33a, R33b, R43, R43a, R51, R53, R53a, R53b, bond "a", and subscript n are described herein.

Synthesis and identification of novel indolo[2,3-a]pyrimido[5,4-c] carbazoles as a new class of anti-cancer agents

A range of 5,6-bisindole and 5-indole-6-(7-azaindole)pyrimidinones were synthesised via a β-keto ester intermediate and a screen of cyclisation conditions undertaken. The optimised route to this new class of indolocarbazoles and azaindolocarbazoles involved photocyclisation, with typical yields of 50-60%. These derivatives were screened for anti-cancer activity via topo II inhibition and the NCI-60 cell line assay, with the screening indicating a lack of topo II inhibition, but significant in vitro growth inhibition within this new chemical class, in the low micromolar range against renal cancer, melanoma and colon cancer cell lines.