17196-75-7

Basic information

• Product Name: (E)-3-AMINO-3-(4-METHYLPHENYL)-2-PROPENENITRILE
• Synonyms: (E)-3-AMINO-3-(4-METHYLPHENYL)-2-PROPENENITRILE;(2E)-3-amino-3-(4-methylphenyl)prop-2-enenitrile
• CAS NO: 17196-75-7
• Molecular Formula: C₁₀H₁₀N₂
• Molecular Weight: 158.2
• Mol File: 17196-75-7.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (E)-3-AMINO-3-(4-METHYLPHENYL)-2-PROPENENITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-3-AMINO-3-(4-METHYLPHENYL)-2-PROPENENITRILE(17196-75-7)
• EPA Substance Registry System: (E)-3-AMINO-3-(4-METHYLPHENYL)-2-PROPENENITRILE(17196-75-7)

Safety Data

• Hazardous Substances Data: 17196-75-7(Hazardous Substances Data)

Upstream product

• 104-85-8 para-methylbenzonitrile 
• 75-05-8 acetonitrile 

Downstream Products

• 1270448-37-7 3-amino-3-p-tolylpropanenitrile 
• 1228571-66-1 (3R)-3-amino-3-p-tolylpropanenitrile 
• 1228561-00-9 (3S)-3-amino-3-p-tolylpropanenitrile 
• 1304048-66-5 (3R)-3-amino-3-p-tolylpropanamide 
• 1307987-76-3 (3S)-3-amino-3-p-tolylpropanamide 
• 59255-25-3 3-oxo-2-phenylhydrazono-3-p-tolyl-propionitrile 

Relevant articles and documents

Enantioselective biocatalytic hydrolysis of β-aminonitriles to β-amino-amides using Rhodococcus rhodochrous ATCC BAA-870

A range of β-aminonitriles (3-amino-3-phenylpropanenitrile and derivatives) were synthesised by reaction of various benzonitriles with acetonitrile and subsequent reduction of the resulting acrylonitrile products. These compounds were hydrolysed to the co

Highly efficient RhI-catalyzed asymmetric hydrogenation of β-amino acrylonitriles

(Figure Presented) It takes two to TangPhos: β-Amino acrylonitriles can be readily prepared from acetonitriles. Both of the E/Z isomers undergo hydrogenation with excellent enantioselectivity by using the Rh-TangPhos (TangPhos = l, 1'-ditert-butyl-(2, 2')-diphospholane) catalyst system. The products, chiral β-amino nitriles, are valuable chiral building blocks for many drugs.

Potential antiarthritic agents. II. Benzoylacetonitriles and β-aminocinnamonitriles

Benzoylacetonitrile and β-aminocinnamonitrile are shown to possess potent intiinflammatory activity in the rat adjuvant arthritis model. In a series of phenyl-substituted analogues, only o-, m-, and p-fluorobenzoylacetonitrile and m- and p-fluoro-β-aminocinnamonitrile retained activity. Additionally, β-amino-2- and β-amino-3-thiopheneacrylonitrile and β-oxo-2- and β-oxo-3-thiophenepropionitrile exhibited similar activity. These agents are not believed to be acting via prostaglandin synthetase inhibition. The metabolic profile of benzoylacetonitrile is also described.