172032-21-2

Basic information

• Product Name: (2-(2,4-dichlorophenyl)-2-methyl-1,3-dioxolan-4-yl)methanol
• Synonyms: (2-(2,4-dichlorophenyl)-2-methyl-1,3-dioxolan-4-yl)methanol
• CAS NO: 172032-21-2
• Molecular Weight: 263.12
• Mol File: 172032-21-2.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (2-(2,4-dichlorophenyl)-2-methyl-1,3-dioxolan-4-yl)methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (2-(2,4-dichlorophenyl)-2-methyl-1,3-dioxolan-4-yl)methanol(172032-21-2)
• EPA Substance Registry System: (2-(2,4-dichlorophenyl)-2-methyl-1,3-dioxolan-4-yl)methanol(172032-21-2)

Safety Data

• Hazardous Substances Data: 172032-21-2(Hazardous Substances Data)

Upstream product

• 56-81-5 glycerol 
• 2234-16-4 1-(2,4-dichlorophenyl)ethan-1-one 

Downstream Products

• 70894-66-5 Benzoic acid (2R,4S)-2-(2,4-dichloro-phenyl)-2-imidazol-1-ylmethyl-[1,3]dioxolan-4-ylmethyl ester 
• 331949-30-5 2-bromomethyl-2-(2,4-dichlorophenyl)-4-phenylcarbonyloxymethyl-1,3-dioxolane 
• 113770-65-3 Toluene-4-sulfonic acid (2R,4R)-2-(2,4-dichloro-phenyl)-2-[1,2,4]triazol-1-ylmethyl-[1,3]dioxolan-4-ylmethyl ester 
• 67914-85-6 cis-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolane-4-methanol 
• 67914-84-5 Benzoic acid (2R,4R)-2-(2,4-dichloro-phenyl)-2-[1,2,4]triazol-1-ylmethyl-[1,3]dioxolan-4-ylmethyl ester 
• 70894-66-5 Benzoic acid (2R,4R)-2-(2,4-dichloro-phenyl)-2-imidazol-1-ylmethyl-[1,3]dioxolan-4-ylmethyl ester 
• 61397-56-6 trans-[2-(Bromomethyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl]methyl benzoate 
• 61397-56-6 (+/-)-cis-[2-(bromomethyl)-2-(2,4-dichlorophenyl)-1,3-dioxolane-4-yl]methyl benzoate 
• 85650-50-6 cis-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-ylmethyl toluene-p-sulphonate 
• 61397-58-8 cis-2-(2,4-Dichlorophenyl)-2-[(1H-imidazol-1-yl)methyl]-1,3-dioxolane-4-methanol 
• 172032-27-8 (2-(2,4-dichlorophenyl)-2-methyl-1,3-dioxolan-4-yl)methyl 4-methylbenzenesulfonate 
• 68751-57-5 2-(2,4-dichlorophenyl)-2-bromomethyl-4-hydroxymethyl-1,3-dioxolane 

Relevant articles and documents

Partial structures of ketoconazole as modulators of the large conductance calcium-activated potassium channel (BKCa)

A series of partial structures of ketoconazole has been synthesized and tested for activity on the large conductance calcium-activated potassium channel (BK) in bovine smooth muscle cells. This has provided openers and blockers of the channel. The results suggest that the phenyl and phenoxy moieties are important for interaction with BK, whereas the imidazole group is unimportant. The properties of the phenoxy moiety seem to determine whether the compounds act to open or block the channel.

Synthesis, antifungal activity and structure-activity relationships of 2-(alkyl or aryl)-2-(alkyl or polyazol-1-ylmethyl)-4-(polyazol-1-ylmethyl)- 1,3-dioxolanes

A series of 2-(alkyl or aryl)-2-(alkyl or polyazol-1-ylmethyl)-4-(polyazol-1-ylmethyl)-1,3-dioxolanes Ia-u was synthesized and tested in vitro against pathogenic fungi in man, animals and plants: Candida albicans, Aspergillus flavus and Fusarium solani. Compounds Iq-t with two polyazol groups have an in vitro activity against these fungi with MIC (minimum inhibitory concentration) value of 5 μg mL-1.