172032-98-3Relevant academic research and scientific papers
Synthesis of Carboxylated Pyrrolidine Derivatives via 1,3-Dipolar Cycloadditions of Homochiral Double-Stabilised E-Azomethine Ylids.
Harwood, L. M.,Lilley, I. A.
, p. 1557 - 1560 (1995)
The preparation and subsequent diastereoselective 1,3- dipolar cycloaddition of E-carboethoxy-substituted azomethine ylids derived by condensating 5-(S)-phenylmorpholinone (1) with ethyl glyoxalate is described.Removal of the chiral template furnishes enantiomerically pure pyrrolidine-2,5-dicarboxylate derivatives.
