172034-34-3

Upstream product

• 72155-45-4 Boc-L-phenylalaninal 
• 172034-33-2 [(S)-1-((R)-3,3-Dichloro-4-oxo-oxetan-2-yl)-2-phenyl-ethyl]-carbamic acid tert-butyl ester 

Relevant academic research and scientific papers

New Approach to the Coupling if γ-Amino β-Hydroxy Acids and ν,γ-Dihydroxy Acids with α-Amino Acid Esters

α,α-Dichloro β-lactones, readily obtained by a highly diastereoselective cycloaddition of dichloroketene to N-Boc-α-amino aldehydes and α-(silyloxy) aldehydes, coupled efficiently with α-amino acid esters leading, after dehalogenation with H2 over 10percent Pd on charcoal, to peptide mimics under mild reaction conditions.

Diastereoselective Cycloaddition of Dichloroketene with α-Oxyaldehydes and α-Amino Aldehydes

A new route to natural products containing 1,2-diol and 1,2-amino alcohol subunits based on the cycloaddition of dichloroketene to α-oxyaldehydes and α-amino aldehydes is demonstrated.