17206-03-0Relevant articles and documents
Gramine Derivatives Targeting Ca2+ Channels and Ser/Thr Phosphatases: A New Dual Strategy for the Treatment of Neurodegenerative Diseases
Lajarín-Cuesta, Rocío,Nanclares, Carmen,Arranz-Tagarro, Juan-Alberto,González-Lafuente, Laura,Arribas, Raquel L.,Araujo De Brito, Monique,Gandía, Luis,De Los Ríos, Cristóbal
, p. 6265 - 6280 (2016/07/26)
We describe the synthesis of gramine derivatives and their pharmacological evaluation as multipotent drugs for the treatment of Alzheimer's disease. An innovative multitarget approach is presented, targeting both voltage-gated Ca2+ channels, cl