31731-23-4

Basic information

• Product Name: 3-(2-NITROETHYL)INDOLE
• Synonyms: 3-(2-NITROETHYL)INDOLE;Nsc63824;3-(2-nitroethyl)-1H-indole
• CAS NO: 31731-23-4
• Molecular Formula: C₁₀H₁₀N₂O₂
• Molecular Weight: 190.1986
• Mol File: 31731-23-4.mol
• Article Data: 30

Chemical Properties

• Boiling Point: 407.5°Cat760mmHg
• Flash Point: 200.2°C
• Appearance: /
• Density: 1.289g/cm³
• Vapor Pressure: 7.53E-07mmHg at 25°C
• Refractive Index: 1.654
• CAS DataBase Reference: 3-(2-NITROETHYL)INDOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-NITROETHYL)INDOLE(31731-23-4)
• EPA Substance Registry System: 3-(2-NITROETHYL)INDOLE(31731-23-4)

Safety Data

• Hazardous Substances Data: 31731-23-4(Hazardous Substances Data)

Usage

General Description

3-(2-NITROETHYL)INDOLE, also known as 3-Nitro-2-Indoline Ethyl Ether, is a chemical compound with the molecular formula C10H10N2O2. It is a member of the indole family and contains a nitro group and an ethyl group attached to the indole ring. 3-(2-NITROETHYL)INDOLE is known for its potential use in various applications, including in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. However, it is also important to note that 3-(2-NITROETHYL)INDOLE may pose health and environmental hazards, and proper handling and disposal procedures should be followed when working with this chemical.

InChI:InChI=1/C10H10N2O2/c13-12(14)6-5-8-7-11-10-4-2-1-3-9(8)10/h1-4,7,11H,5-6H2

Upstream product

• 120-72-9 indole 
• 3638-64-0 1-nitroethylene 
• 63971-99-3 ethyl 3-(1H-indol-3-yl)-2-nitropropanoate 
• 3156-51-2 3-[(E)-2-nitroeth-1-enyl]-1H-indole 
• 687-51-4 H-L-Leu-NH₂ 
• 113747-79-8 butyl 3-(3-indolyl)-2-methyl-2-nitropropionate 
• 75-52-5 nitromethane 
• 620598-21-2 (N-triisopropylsilyl-1H-indol-3-yl)-N,N,N-trimethylmethanaminium iodide 
• 87-52-5 3-(Dimethylaminomethyl)indole 
• 2483-57-0 methyl 2-nitroacetate 
• 1309601-79-3 C₁₀H₁₀N₂O₃ 
• 3156-51-2 3-(2-nitroethenyl)-1H-indole 
• 487-89-8 Indole-3-carboxaldehyde 
• 626-35-7 nitroacetic acid ethyl ester 

Downstream Products

• 61-54-1 tryptamine 
• 98664-54-1 C₁₇H₁₅ClN₂O 
• 213841-85-1 C₁₈H₁₈N₂O₂ 
• 98664-55-2 C₁₇H₁₅BrN₂O 
• 128593-27-1 C₁₉H₁₈N₂O 
• 128593-33-9 1-((E)-Styryl)-1,3,4,9-tetrahydro-β-carbolin-2-ol 
• 771-51-7 indole-3-acetonitrile 
• 2776-06-9 (1H-Indol-3-yl)acetaldehyde oxime 
• 1007893-74-4 (4-hydroxyphenyl)(9H-pyrido[3,4-b]indol-1-yl)methanone 
• 1007893-76-6 (3-bromo-4-hydroxyphenyl)(9H-pyrido[3,4-b]indol-1-yl)methanone 
• 1007893-78-8 (3,5-dibromo-4-hydroxyphenyl)(9H-pyrido[3,4-b]indol-1-yl)methanone 

Relevant articles and documents

Synthesis and receptor-affinity profile of N-hydroxytryptamine derivatives for serotonin and tryptamine receptors. A molecular-modeling study.

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2D-2D Nanocomposite of MoS2-Graphitic Carbon Nitride as Multifunctional Catalyst for Sustainable Synthesis of C3-Functionalized Indoles

A nanocomposite of two-dimensional MoS2 supported on graphitic C3N4 nanosheets has been prepared by a facile ultrasonication method followed by demonstrating its ability to catalyze the synthesis of several indole derivatives. The as-prepared nanocomposite catalyst was characterized in detail by using different microscopic and spectroscopic techniques to understand its structure and physicochemical properties. Subsequently, this nanocomposite catalyst was used as a heterogeneous multifunctional catalyst to synthesize several C3-functionalized indoles in the aqueous medium. The employed strategy also provided very good catalyst recyclability and versatility for the synthesis of various precursors of medicinally significant indoles, such as serotonin, melatonin, and various β-carboline alkaloids. In addition, a natural product derivate has been prepared on the gram-scale by using this methodology. Furthermore, high atom economy (100 %) and lower E-factor (0.042) makes this strategy a sustainable approach for the synthesis of C3-functionalized indoles.

Indole derivative and uses thereof

The present invention relates to an indole derivative and uses thereof, wherein the compound and the pharmaceutical composition comprising the compound can be used for antagonizing orexin receptors. The present invention further relates to a method for preparing the compound and the pharmaceutical composition, and uses of the compound and the pharmaceutical composition in treatment or prevention of diseases associated with orexin receptors.