172147-72-7

Upstream product

• 108-59-8 malonic acid dimethyl ester 
• 162222-93-7 (1R,2R)-2-((2S,3S,4R,5R,6S)-3,4,5-Tris-benzyloxy-6-methyl-tetrahydro-pyran-2-yloxy)-cyclohexanol 
• 172147-70-5 3-[(1R,2R)-2-((2S,3S,4R,5R,6S)-3,4,5-Tris-benzyloxy-6-methyl-tetrahydro-pyran-2-yloxy)-cyclohexyloxy]-propan-1-ol 
• 172147-69-2 (2S,3S,4R,5R,6S)-2-[(1R,2R)-2-(3-Allyloxy-propoxy)-cyclohexyloxy]-3,4,5-tris-benzyloxy-6-methyl-tetrahydro-pyran 

Relevant academic research and scientific papers

Malonic acid derivatives as sialyl Lewis X mimetics

Malonic acid derivatives designed as mimetics of the sialyl Lewis X determinant were synthesized. Their inhibitory potency for selectin mediated cell adhesion was evaluated in cell culture assays and in vivo. The receptor binding affinity for E- and P-selectins of simple mimetics was found to be comparable to the potency of the tetrasaccharide sialyl Lewis X.