17215-77-9

Basic information

• Product Name: 2,2-dichloro-2,3-dihydro-1H-inden-1-one
• CAS NO: 17215-77-9
• Molecular Formula: C₉H₆Cl₂O
• Molecular Weight: 201.0493
• Mol File: 17215-77-9.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 292.8°C at 760 mmHg
• Flash Point: 122.4°C
• Density: 1.42g/cm³
• Vapor Pressure: 0.00179mmHg at 25°C
• Refractive Index: 1.603
• CAS DataBase Reference: 2,2-dichloro-2,3-dihydro-1H-inden-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-dichloro-2,3-dihydro-1H-inden-1-one(17215-77-9)
• EPA Substance Registry System: 2,2-dichloro-2,3-dihydro-1H-inden-1-one(17215-77-9)

Safety Data

• Hazardous Substances Data: 17215-77-9(Hazardous Substances Data)

Usage

Structure

Cyclic enone
A type of organic compound that features a carbon ring with a carbonyl group (C=O) and double bond (C=C) within the ring.

Chlorine atoms

Two
The compound has two chlorine atoms attached to the carbon ring, which can influence its reactivity and properties.

Building block in organic synthesis

Yes
2,2-dichloro-2,3-dihydro-1H-inden-1-one is used as a starting material or intermediate in the synthesis of more complex organic compounds.

Reactive intermediate

Yes
The compound can be found as a reactive intermediate in various chemical processes, meaning it is involved in multiple steps of a reaction sequence.

Applications

Pharmaceutical, agrochemical, and industrial chemicals
It is used in the production of various chemicals, including those in pharmaceuticals, agrochemicals (e.g., pesticides), and other industrial applications.

Hazardous properties

Harmful if ingested, inhaled, or in contact with skin or eyes
Proper handling and safety precautions are necessary to avoid potential health risks associated with this compound.

Upstream product

• 6351-10-6 1-Indanol 
• 83-33-0 inden-1-one 

Downstream Products

• 1579-14-2 2-chloroindanone 
• 119870-84-7 2-chloro-2-indene-1-one 
• 83-33-0 inden-1-one 

Relevant articles and documents

A Simple and Efficient Method for the Preparation of α-Halogenated Ketones Using Iron(III) Chloride and Iron(III) Bromide as Halogen Sources with Phenyliodonium Diacetate as Oxidant

α-Halogenated ketones are both unique structure moieties existing in biologically natural products and valuable synthetic intermediates for the preparation of functional molecules. An efficient and scalable method for the preparation of α-halogenated ketone using iron (III) chloride and iron (III) bromide as halogen sources with phenyliodonium diacetate as oxidant has been developed, featuring mild reaction conditions, environmentally friendly reagents, and wide substrate scope. Notably, the three-step synthesis of drug prasugrel was achieved using this developed method as a key step with 30% yield on gram-scale. Additionally, the reaction mechanism involving chloride cation was proposed based on some preliminary control experiments. (Figure presented.).

The use of sodium chlorate/hydrochloric acid mixtures as a novel and selective chlorination agent

Sodium chlorate/hydrochloric acid mixtures were used to chlorinate activated arenes and the α-position of ketones. This chlorination method was used to produce selectively mono-, di-, and trichlorinated compounds by controlling the molarity of sodium chlorate. This reagent proved to be much more efficient and easier to handle than chlorine gas.

2-Chloropyridazin-3(2H)-ones as electrophilic chlorinating agents: Effective α-chlorination of active methylene/methine compounds

2,4,5-Trichloro- (2a) and 2,4-dichloro-5-methoxypyridazin-3(2H)-one (2b) are novel electrophilic chlorinating agents. α-Chlorination of active methylene/methine compounds with 2 in the presence of either Lewis or protonic acids in dichloromethane (for Lewis acid) or water (for protonic acid or none) at room temperature gave also selectively α-monochlorides and/or α,α-dichlorides in good to excellent yields.