6351-10-6

Basic information

• Product Name: 1-INDANOL
• Synonyms: 1-Indanol, 98% 10GR;1-Hydroxyhydrindene 1-Indanol;1-Indanol 98%;(+/-)-1-INDANOL;1-INDANOL;1-INDANAOL;1-HYDROXYHYDRINDENE;1H-INDEN-1-OL, 2,3-DIHYDRO-
• CAS NO: 6351-10-6
• Molecular Formula: C₉H₁₀O
• Molecular Weight: 134.18
• EINECS: 228-755-3
• Product Categories: pharmacetical
• Mol File: 6351-10-6.mol
• Article Data: 204

Chemical Properties

• Melting Point: 50-53 °C
• Boiling Point: 128 °C12 mm Hg(lit.)
• Flash Point: 145 °C
• Appearance: White to slightly yellow/Crystalline Solid
• Density: 0.8540 (rough estimate)
• Refractive Index: 1.5630 (estimate)
• Storage Temp.: Store at RT.
• Solubility: Chloroform (Sparingly), Methanol (Slightly)
• PKA: 14.23±0.20(Predicted)
• Water Solubility: Soluble in water 10 g/L at 20°C, ethanol, benzene.
• BRN: 2042960
• CAS DataBase Reference: 1-INDANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 1-INDANOL(6351-10-6)
• EPA Substance Registry System: 1-INDANOL(6351-10-6)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 22-36/37/38
• Safety Statements: 26-36
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 3
• RTECS: NK7300000
• HazardClass: 6.1(b)
• PackingGroup: III
• Hazardous Substances Data: 6351-10-6(Hazardous Substances Data)

Usage

Uses

1-Indanol derivative was found to be an efficient ligand for the palladium-catalyzed asymmetric Heck reaction. It is used as pharmaceutical intermediate.

General Description

Chiral-sensitive aggregation of 1-indanol has been studied by FTIR spectroscopy. Transfer dehydrogenation of 1-indanol has been investigated over heterogeneous palladium catalyst using cyclohexene as hydrogen acceptor.

InChI:InChI=1/C9H10O/c10-9-6-5-7-3-1-2-4-8(7)9/h1-4,9-10H,5-6H2

Upstream product

• 10368-44-2 trans-2-bromo-1-indanol 
• 83-33-0 inden-1-one 
• 64-17-5 ethanol 
• 199924-88-4 di(1-indanyl) ether 
• 7732-18-5 water 
• 95-13-6 1-indene 
• 496-11-7 INDANE 
• 72347-40-1 1-indanol THP ether 
• 138784-03-9 ((1H-inden-3-yl)oxy)(tert-butyl)dimethylsilane 
• 108-98-5 thiophenol 
• 623-73-4 diazoacetic acid ethyl ester 
• 103394-88-3 (2,3-dihydro-1H-inden-1-yl) (phenyl) sulfide 
• 75-05-8 acetonitrile 
• 104023-28-1 3-trifluoroacetoxy-2,3-dihydroindene 

Downstream Products

• 697-64-3 (R)-indan-1-ol 
• 25501-32-0 (S)-indanol 
• 68567-23-7 (S)-(-)-2,3-dihydro-1H-inden-yl acetate 
• 879-35-6 (R)-1-indanyl acetate 
• 18531-99-2 (S)-[1,1']-binaphthalenyl-2,2'-diol 
• 158529-97-6 (R)-1-indanyl butyrate 
• 95-13-6 1-indene 
• 35275-62-8 1-chloroindane 
• 90172-23-9 1-indanyl p-fluorobenzoate 
• 83-33-0 inden-1-one 
• 106-93-4 ethylene dibromide 
• 93008-98-1 N-(2,3-dihydro-1H-inden-1-yl)-4-methylbenzene sulfonamide 
• 496-11-7 INDANE 
• 902-25-0 1-indanone 2,4-dinitrophenylhydrazone 

Relevant articles and documents

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Pincerlike molybdenum complex and preparation method thereof, catalytic composition and application thereof, and alcohol preparation method

The invention discloses a clamp-type molybdenum complex, a preparation method, a corresponding catalyst composition and application. The method comprises the steps: obtaining 9 molybdenum complexes with different structures through coordination reaction of 2-(substituent ethyl)-(5, 6, 7, 8-tetrahydroquinolyl) amine and a corresponding carbonyl molybdenum metal precursor; and catalyzing a ketone compound transfer hydrogenation reaction through a molybdenum complex to generate 40 alcohol compounds. The preparation method of the molybdenum complex is simple, high in yield and good in stability. For a transfer hydrogenation reaction of ketone, the molybdenum-based catalytic system has high catalytic activity and small molybdenum loading capacity, is used for production of aromatic and aliphatic alcohols, and has the advantages of simple method, small environmental pollution and high yield.

Selective Aerobic Oxidation of Secondary C (sp3)-H Bonds with NHPI/CAN Catalytic System

Abstract: The direct aerobic oxidation of secondarty C(sp3)-H bonds was achieved in the presence of N-hydroxyphthalimide (NHPI) and cerium ammonium nitrate (CAN) under mild conditions. Various benzylic methylenes could be oxidized to carbonyl compounds in satisfied selectivity while saturated cyclic alkanes could be further oxidized to the corresponding lactones with the catalytic system. Remarkably, 25% of isochroman was converted to corresponding ketone with a selectivity of 96%. The reaction was initiated by hydrogen atom abstraction from NHPI by cerium and nitrates under oxygen atmosphere to form PINO radicals. 2,2,6,6-Tetramethylpiperidine-1-oxyl (TEMPO) addition experiments showed that the oxidation proceeded via a complex radical chain mechanism and an ion pathway. Graphic Abstract: [Figure not available: see fulltext.]