172160-54-2Relevant academic research and scientific papers
Replacement of the phosphodiester linkage in oligonucleotides by a C=C double bond: Comparison of the cis and trans isomers
Wendeborn, Sebastian,Wolf, Romain M.,De Mesmaeker, Alain
, p. 6879 - 6882 (1995)
The two olefinic backbone replacements III and IV were synthesized and incorporated into oligonucleotides. The hybridization properties of the modified oligonucleotides to DNA and RNA complements and conformational analyses of III and IV are compared to the corresponding amide modifications I and II.
