172161-52-3

Upstream product

• 172161-67-0 5'-S-acetyl-N⁴-benzoyl-3'-O-tert-butyldimethylsilyl-2',5'-dideoxy-5'-thiocytidine 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 172161-64-7 5'-S-acetyl-N⁴-benzoyl-2',5'-dideoxy-5'-thiocytidine 
• 4836-13-9 N₄-benzoyl-2'-deoxycytidine 

Relevant academic research and scientific papers

A versatile approach to the synthesis of oligonucleotide analogs containing neutral 5′-thioformacetal internucleoside linkages

Activation of nucleoside donors 5 by sulfuryl chloride followed by the addition of 5′-thionucleoside acceptors 3 yields 5′-thioformacetal dinucleotide analogs 6 with in situ trapping of liberated methanesulfenyl chloride with cyclohexene. Purine as well a

A versatile approach to the synthesis of dinucleotide analogs containing neutral 5'-thioformacetal internucleoside linkages

Activation of nucleoside donors 5 by sulfuryl chloride followed by the addition of 5'-thionucleoside acceptors 3 yields 5'-thioformacetal dinucleotide analogs 6 with in situ trapping of liberated methanesulfenyl chloride with cyclohexene. Purine as well as pyrimidine derivatives can be part of a coupling reaction as nucleoside donors or acceptors. The dimethoxytrityl protecting group is compatible with the present coupling methodology allowing differential 3',5'-end protection with concomitant orthogonal base protection.